CD8 T Cell Exhaustion in Cancers And IBD

Tianyi Bi

doi:10.54097/yxgvsr79

Authors

Tianyi Bi

DOI:

https://doi.org/10.54097/yxgvsr79

Keywords:

CD8T cells, glutamine, hepatocellular carcinoma, IBD, cholesterol.

Abstract

People are increasingly at risk of inflammatory bowel disease and tumours due to diet and lifestyle. CD8T cells are immune cells, but they are frequently depleted. So far, the relationship between CD8T exhaustion and disease is unclear, and the relationship needs to be sought for further treatment. In the study, changes in glutamine levels in CD8T cells and hepatocellular carcinoma cells were found to influence CD8T cell depletion and replicative expression in hepatocellular carcinoma. Regarding the pathogenic factors of IBD, the depletion of CD8T cells has been found to be associated with the pathogenic factors of IBD. Tumours are favoured by changes in cholesterol levels in the tumour microenvironment. In this study, we investigated the mechanism of CD8T cell depletion in inflammation and tumors.

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