Current Study on Deep Brain Stimulation for Parkinson's Disease
DOI:
https://doi.org/10.54097/khxzf539Keywords:
Deep brain stimulation, STN-DBS, Gpi-DBS, Vim-DBS, PPN-DBS.Abstract
This paper emphasizes the evolution and application of neural electrical stimulation in the context of Parkinson's disease. During the last several decades, Deep Brain Stimulation (DBS) has become a highly successful viable treatment choice for patients with advanced stages of PD and other motor disorders. DBS utilizes a device similar to a pacemaker to administer constant electrical signals to targeted regions within the brain to help patient relieve the symptoms. The DBS has been involved in the rehabilitation process of more than 80000 people, and most of them are patients with PD. Based on the specific symptoms show by patients, several targets have been approved as effective DBS targets for patients with PD. These include subthalamic nucleus (STN), globus pallidus internus (GPi), ventral intermediate nucleus (Vim), and pedunculopontine nucleus (PPN). Hence, understanding the applications and evolution of DBS techniques have significant importance for future studies of PD and brain functions.
Downloads
References
DeMaagd G, Philip A. Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. P T. 2015, 40 (8): 504-32.
Willis AW, Roberts E, Beck JC, Fiske B, Ross W, Savica R, Van Den Eeden SK, Tanner CM, Marras C, Alcalay R, et al. Incidence of parkinson disease in North America. npj Parkinson’s Disease. 2022, 8 (1).
Yahya K. The basal ganglia corticostriatal loops and conditional learning. Reviews in the Neurosciences. 2020, 32 (2):181–190.
Kandel, E. R., Koester, J. D., Mack, S. H., & Siegelbaum, S. A. Principles of Neural Science. McGraw-Hill. 2021. 292.
Sivanandy P, Leey TC, Xiang TC, Ling TC, Wey Han SA, Semilan SL, Hong PK. Systematic review on parkinson’s disease medications, emphasizing on three recently approved drugs to control parkinson’s symptoms. International Journal of Environmental Research and Public Health. 2021; 19 (1): 364.
Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E, Bergman H. Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 2011; 72 (2): 370–384.
Sironi VA. Origin and evolution of deep brain stimulation. Frontiers in Integrative Neuroscience. 2011; 5.
Gardner J. A history of deep brain stimulation: Technological Innovation and the role of Clinical Assessment Tools. Social Studies of Science. 2013, 43 (5): 707–728.
Goetz CG. The history of parkinson’s disease: Early clinical descriptions and neurological therapies. Cold Spring Harbor Perspectives in Medicine. 2011, 1 (1).
Hariz MI, Blomstedt P, Zrinzo L. Deep brain stimulation between 1947 and 1987: The untold story. Neurosurgical Focus. 2010, 29 (2).
Gildenberg PL. Fifty years of stereotactic and functional neurosurgery. In: Barrow DL, Kondziolka DS, Laws ER, Jr, Traynelis VC. (eds) Fifty Years of Neurosurgery. New York, NY: Lippincott Williams & Wilkins. 2000. 295–320.
Benabid AL, Pollak P, Hoffmann D, Gervason C, Hommel M, Perret JE, de Rougemont J, Gao DM. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. The Lancet. 1991, 337 (8738): 403–406.
Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science. 1990; 249 (4975): 1436–1438.
Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, Benabid A-L. Electrical stimulation of the subthalamic nucleus in Advanced Parkinson’s Disease. New England Journal of Medicine. 1998; 339 (16): 1105–1111.
Basinger H, Joseph J. Neuroanatomy, Subthalamic Nucleus. 2023.
Li H, Liang S, Yu Y, Wang Y, Cheng Y, Yang H, Tong X. Effect of subthalamic nucleus deep brain stimulation (STN-DBS) on balance performance in parkinson’s disease. PLOS ONE. 2020; 15 (9).
Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E, Bergman H. Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 2011, 72 (2): 370–384.
Javed N, Cascella M. Neuroanatomy, Globus Pallidus. 2023.
Odekerken VJ, Boel JA, Geurtsen GJ, Schmand BA, Dekker IP, de Haan RJ, Schuurman PR, de Bie RM. Neuropsychological outcome after deep brain stimulation for parkinson disease. Neurology. 2015, 84 (13): 1355–1361.
Bertino S, Basile GA, Bramanti A, Ciurleo R, Tisano A, Anastasi GP, Milardi D, Cacciola A. Ventral intermediate nucleus structural connectivity-derived segmentation: Anatomical reliability and variability. NeuroImage. 2021, 243: 118519.
Lozano AM. Vim thalamic stimulation for tremor. Archives of Medical Research. 2000; 31 (3): 266–269.
French IT, Muthusamy KA. A review of the pedunculopontine nucleus in parkinson’s disease. Frontiers in Aging Neuroscience.
Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe parkinson’s disease. Brain. 2007, 130 (6): 1596–1607.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.







