Oral Health: The Potential of Mesenchymal Stem Cells in Treating Various Oral Diseases and Promoting Tissue Regeneration

Authors

  • Yifan Wang

DOI:

https://doi.org/10.54097/fsdnwy80

Keywords:

Tissue regeneration, Mesenchymal stem cells, Periodontal Ligament Stem Cells, Oral Diseases.

Abstract

The WHO Global Oral Health Status Report (2022) estimates that over 3.5 billion individuals worldwide have an oral disease. Most of the cases are dental caries, periodontal disease, tooth loss etc. Tooth loss will not only affect the balance of the oral environment but also cause negative effects on facial development and the patient's psychological condition. At present, The implement of oral stem cells to encourage tissue regeneration has become a hot trend. Among them, Periodontal Ligament Stem Cells (PDLSCs) and Dental Follicle Stem Cells (DFSCs) have been discovered it’s potential to promote tooth regeneration. Scientists proposed a variety of different treatment methods, including the use of advanced bioengineered technology to further target different oral diseases. So far, It is firmly established that oral stem cells have the potential to boost tissue regeneration.

Downloads

Download data is not yet available.

References

Huang Y, et al. Lipopolysaccharide-Preconditioned Dental Follicle Stem Cells Derived Small Extracellular Vesicles Treating Periodontitis via Reactive Oxygen Species/Mitogen-Activated Protein Kinase Signaling-Mediated Antioxidant Effect. Int J Nanomedicine, 2022, 17:799-819.

Wada N, et al. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol.2009, 219(3):667-76

Wada N, et al. Immunomodulatory Properties of PDLSC and Relevance to Periodontal Regeneration. Curr Oral Health Rep 2, 245–251 (2015).

Németh K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med, 2009, 15(1):42-9.

Shi M, et al. Deproteinized bovine bone matrix induces osteoblast differentiation via macrophage polarization. J Biomed Mater Res A. 2018 May;106(5):1236-1246.

Liu J, et al. Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration. Stem Cell Res Ther, 2019, 10(1):320.

Gronthos S, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A, 2000, 97(25):13625-30.

Khorsand A, et al. Autologous dental pulp stem cells in regeneration of defect created in canine periodontal tissue. J Oral Implantol, 2013, 39(4):433-43.

Huang GT, et al. Challenges of stem cell-based pulp and dentin regeneration: a clinical perspective. Endod Topics, 2013, 28(1):51-60.

Lee CH, et al. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof-of-concept study. 2010, 376(9739):440-8.

Kim K, et al. Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res. 2010, 89(8):842-7.

Hu B, et al. Tissue engineering of tooth crown, root, and periodontium. Tissue Eng, 2006, 12(8):2069-75.

Cai J, et al. Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells. Cell Regen, 2013, 30;2(1):6.

Honda M, et al. Rat costochondral cell characteristics on poly (L-lactide-co-epsilon-caprolactone) scaffolds. Biomaterials, 2003, 24(20):3511-9.

Oshima M, et al. Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy. PLoS One, 2011, 6(7): e21531.

Downloads

Published

29-12-2023

How to Cite

Wang, Y. (2023). Oral Health: The Potential of Mesenchymal Stem Cells in Treating Various Oral Diseases and Promoting Tissue Regeneration. Highlights in Science, Engineering and Technology, 74, 901-907. https://doi.org/10.54097/fsdnwy80