The Biological Function and Tumorigenesis Of ERK/MAPK Signaling in Melanoma

Abstract

Melanoma, as a potentially lethal malignant tumor, has been increasing worldwide. As an aggressive and lethal skin cancer, discover the malignant melanoma at an early stage can reduce mortality. The deeper the tumor, the more difficult the prognosis of the melanoma, Timely detection and rapid treatment of melanoma is very important for the diagnosis of melanoma. Because the treatment of melanoma is resistant to conventional chemotherapy, the direction of treatment has shifted to molecular targeted therapy. The MAPK pathway is a central signal transduction element that regulates basic physiological activities such as cell proliferation and apoptosis, the occurrence and development of tumors. The over-activation of ERK Assume a pivotal role. RAS/Raf/MAPK (MEK) /ERK pathway is a part of the MAPK signaling pathway, which is the most pivotal signaling cascade. RAS/Raf/ MEK/ERK (MAPK) pathway inhibitors have shown significant results in the clinical treatment of tumors, and can slow the development of the disease. In this review, we discussed the principles, methods and recent progress in the targeted therapy of melanoma.of the ERK/MAPK pathway.