The Mechanism of Tumor Metastasis
DOI:
https://doi.org/10.54097/s7g2ke57Keywords:
Angiogenesis, EMT, invasion, intravasation, extravasation.Abstract
Nowadays, cancer is the leading cause of human health problems, and the vast majority of deaths are caused by metastatic cancer. The disease is not easy to detect in the early stage, in a latent state, after a period of time, is found to be in an advanced stage, difficult to cure. The current treatment methods include chemotherapy, radiotherapy, surgery, anti-cancer drugs, etc., after clinical application, there is a little basis but also has its limitations. In particular, there are many studies on the mechanism of action of a series of factors that cause tumor metastasis, the specific cause of metastasis is still unclear, which brings challenges to the treatment of metastatic tumors. This article reviews the basic definition and characteristics of cancer, the process of tumor metastasis, describes the known influencing factors, and explores possible targeted therapies. It is hoped that this will help and inspire future research into cancer treatments.
Downloads
References
Mattiuzzi C, Lippi G. Current Cancer Epidemiology. J Epidemiol Glob Health. 2019; 9 (4): 217-222.
Pereira-Veiga T, Schneegans S, Pantel K, Wikman H. Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance. Cell Rep. 2022; 40 (9): 111298.
Vinod SK, Hau E. Radiotherapy treatment for lung cancer: Current status and future directions. Respirology. 2020; 25 Suppl 2: 61-71.
Dhanasekaran R, Deutzmann A, Mahauad-Fernandez WD, Hansen AS, Gouw AM, Felsher DW. The MYC oncogene - the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol. 2022; 19 (1): 23-36.
Aibixin, Mechanism and Research of Tumor Angiogenesis, 2022-05-162023-09-15, https://baijiahao.baidu.com/s?id=1732950875824503323&wfr=spider&for=pc.
Bhat SM, Badiger VA, Vasishta S, Chakraborty J, Prasad S, Ghosh S, Joshi MB. 3D tumor angiogenesis models: recent advances and challenges. J Cancer Res Clin Oncol. 2021 Dec; 147 (12): 3477-3494.
Castaneda M, den Hollander P, Kuburich NA, Rosen JM, Mani SA. Mechanisms of cancer metastasis. Semin Cancer Biol. 2022; 87: 17-31.
Lugano R, Ramachandran M, Dimberg A. Tumor angiogenesis: causes, consequences, challenges and opportunities. Cell Mol Life Sci. 2020; 77 (9): 1745-1770.
Bakir B, Chiarella AM, Pitarresi JR, Rustgi AK. EMT, MET, Plasticity, and Tumor Metastasis. Trends Cell Biol. 2020 Oct; 30 (10): 764-776.
Huang Y, Hong W, Wei X. The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol. 2022; 15(1): 129. Published 2022 Sep 8.
Liu Q, Ma Z, Cao Q, et al. Perineural invasion-associated biomarkers for tumor development. Biomed Pharmacother. 2022; 155: 113691.
Chiang SP, Cabrera RM, Segall JE. Tumor cell intravasation. Am J Physiol Cell Physiol. 2016; 311 (1): C1-C14.
Lin D, Shen L, Luo M, et al. Circulating tumor cells: biology and clinical significance. Signal Transduct Target Ther. 2021; 6 (1): 404. Published 2021 Nov 22.
Kim S, Wan Z, Jeon JS, Kamm RD. Microfluidic vascular models of tumor cell extravasation. Front Oncol. 2022; 12: 1052192. Published 2022 Nov 11.
Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013; 19 (11): 1423-1437.
Elia I, Haigis MC. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nat Metab. 2021; 3 (1): 21-32.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Highlights in Science, Engineering and Technology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
