Application of Natural Killer Cells in Cancer Treatment and Its Clinical Progress
DOI:
https://doi.org/10.54097/nh4kaj19Keywords:
Natural killer cells, Cancer immunotherapy, NK cell activation, NK cell cytotoxicity, Anti-tumor therapy.Abstract
One type of effector lymphocyte that is crucial to the innate immunity is the natural killer (NK) cell. With the increasing interests in immunotherapy, the value of NK cells utilization on treating cancers is gradually being recognized and thus is transforming to be proved by current clinical trials. NK-based cancer immunotherapy results in unique cytotoxic functions in a more direct and straightforward manner which targets both hematologic cancers as well as solid tumors. Concurrently, several clinical obstacles are encountered, including immunological escape, hardship of tumor access, and effector cell fratricide, which all await to be solved and require further studies on promoting the effectiveness while remaining immuno-safety. Pleasantly, multitudinous corresponding solutions are flourishing, and researchers are using their best endeavors to accelerate positive progress in NK-based immunotherapy. Believing in a promising future of NK-related cancer immunotherapy, this review will concentrate on NK cells’ effector functions towards cancers, including the cellular mechanisms, present experimental progresses, and challenges which need to be addressed.
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