Relationship Between Structure and Pathogenicity
DOI:
https://doi.org/10.54097/wmckz126Keywords:
COVID-19, variants, pathogenicity.Abstract
The global COVID-19 crisis caused by the SARS-CoV-2 virus has led to the emergence of multiple variants, capturing substantial international attention. This extensive study offers a comprehensive examination of the structural attributes and disease-causing potential of the original SARS-CoV-2 strain and its primary variants, namely Alpha, Beta, Delta, Gamma, and Omicron.
Downloads
References
Huang, Y., Yang, C., Xu, Xf. et al. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacol Sin 41, 1141–1149 (2020).
Hu, B., Guo, H., Zhou, P. et al. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol 19, 141–154 (2021).
Trobec, Tomaž. The role of the SARS-CoV-2 envelope protein as a pH-dependent cation channel. The Journal of physiology vol. 599, 14 (2021).
Kumar, Sudhir et al. An Evolutionary Portrait of the Progenitor SARS-CoV-2 and Its Dominant Offshoots in COVID-19 Pandemic. Molecular biology and evolution vol. 38, 8 (2021): 3046-3059.
Zhang, Lizhou et al. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv: the preprint server for biology 2020.06.12.148726.
Meng, Bo et al. Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7. Cell reportsvol. 35, 13 (2021): 109292.
Davies, Nicholas G et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science (New York, N.Y.) vol. 372, 6538 (2021): eabg3055.
Mahase, Elisabeth. Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant. BMJ (Clinical research ed.) vol. 372 n296. 1 Feb. 2021.
Tegally, Houriiyah et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature vol. 592, 7854 (2021): 438-443.
Harvey, William T et al. SARS-CoV-2 variants, spike mutations and immune escape. Nature reviews. Microbiology vol. 19, 7 (2021): 409-424.
Baum, Alina et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science (New York, N.Y.) vol. 369, 6506 (2020): 1014-1018.
Garcia-Beltran, Wilfredo F et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell vol. 184, 9 (2021): 2372-2383.e9.
Li, Baisheng et al. Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant. Nature communications vol. 13, 1 460. 24 Jan. 2022
Earnest, Rebecca et al. “Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA.” medRxiv: the preprint server for health sciences 2021.10.06.21264641. 7 Oct. 2021.
Zhang, Jun et al. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. bioRxiv: the preprint server for biology 2021.08.17.456689. 17 Aug. 2021.
Hart, William S et al. Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis. The Lancet. Infectious diseases vol. 22, 5 (2022): 603-610.
Lupala, Cecylia S et al. “Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor.” Biochemical and biophysical research communications vol. 590 (2022): 34-41.
Vu, Michelle N et al. Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection. bioRxiv: the preprint server for biology 2023.04.17.536926. 10 Jul. 2023.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Highlights in Science, Engineering and Technology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
