Drug Discovery and Development of Lecanemab

Abstract

Alzheimer's disease is one of the most prevalent types of senile dementia; the patient's thinking, memory, and independence will be compromised; the patient's quality of life will be impacted; and the patient may even pass away. As the disease becomes more prevalent in today's society, the financial burden on healthcare providers also rises; The beta-amyloid (Aβ) cascade hypothesis is A widely recognized mechanism of AD, and the imbalance between the overproduction and clearance of Aβ is the initial event leading to neuronal degeneration and dementia. The discovery and development of Lecanemab has brought new hope to mankind. By researching and sorting out relevant experiments and literatures, we have explored the discovery of drugs, preclinical research, clinical research, drug development and its impact on biomedicine, and obtained some directions for future research. Lecanemab can significantly slow down the rate of cognitive function decline, promote the basic research and drug therapy research and development related to AD, and also has important implications for the research and development of future drugs, promote the innovation and progress of the pharmaceutical industry, and is expected to become a new drug for the treatment of AD.