The Mechanism of Chemotherapy Toxicity to the Hippocampus and its Intervention Measures
DOI:
https://doi.org/10.54097/44mxys73Keywords:
Chemotherapy toxicity, hippocampus, intervention measures.Abstract
This article explores the comprehensive recovery strategies necessary for individuals following chemotherapy, focusing on a holistic approach that includes medications, lifestyle changes, and environmental interventions. The initial section delves into the importance of personalized medical interventions such as targeted therapies, immunotherapy and hormonal treatments, highlighting their critical role in effectively controlling cancer while minimizing side effects. Detailed focus on the mechanisms of adverse effects, particularly the neurotoxic effects of chemotherapy drugs on the hippocampus, elucidates the biological basis of chemotherapy-induced cognitive impairment (often referred to as "chemo brain"). Environmental interventions are another core component of recovery strategies focused on reducing toxin exposure and creating therapeutic spaces conducive to recovery. Provides practical advice for achieving a healthier living environment, including choosing organic foods, using natural household products, and improving indoor air quality. The findings presented here provide a fundamental understanding of brain structural changes following chemotherapy, providing insights into potential mitigation strategies for cognitive recovery.
Downloads
References
Dietrich J, Prust M, Kaiser J. Chemotherapy, cognitive impairment and hippocampal toxicity. Neuroence, 2015:224-232.
Winocur G. Chemotherapy-Induced Cognitive Impairment and Hippocampal Neurogenesis: A Review of Physiological Mechanisms and Interventions. International Journal of Molecular Sciences, 2021, 22.
Mounier N M, Abdel-Maged E S, Wahdan S A, et al. Chemotherapy-induced cognitive impairment (CICI): An overview of etiology and pathogenesis. Life Sciences, 2020, 258(3):118071.
Bagnall-Moreau C, Chaudhry S, Salas-Ramirez K, et al. Chemotherapy-Induced Cognitive Impairment Is Associated with Increased Inflammation and Oxidative Damage in the Hippocampus. Molecular neurobiology, 2019, 56(10):7159-7172.
Gaman A M, Uzoni A, Popa-Wagner A, et al.The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-"Chemobrain".Aging & Disease, 2016, 7(3):307-317.
Carter B W, Altan M, Shroff G S, et al. post-chemotherapy and targeted therapy imaging of the chest in lung cancer. Clinical Radiology, 2022, 77(1): e1-e10.
Lee K A, Kim H R, Yoon S Y. Rheumatic complications in cancer patients treated with immune checkpoint inhibitors. The Korean Journal of Internal Medicine, 2019, 34(6): 1197.
Sartor O, Flood E, Beusterien K, et al. Health-related quality of life in advanced prostate cancer and its treatments: biochemical failure and metastatic disease populations. Clinical Genitourinary Cancer, 2015, 13(2): 101-112.
Cassileth B R. Psychiatric benefits of integrative therapies in patients with cancer. International Review of Psychiatry, 2014, 26(1): 114-127.
Doran C. Prescribing mental health medication: the practitioner's guide. Routledge, 2021.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Highlights in Science, Engineering and Technology

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.







