Effects Of Sickle Cell Traits on Malaria

Abstract

Background: Malaria continues to be a significant public health concern in Africa, posing a threat to the population. Malaria causes damage to various body systems, including the gastrointestinal and nervous systems, as well as metabolic abnormalities. However, effective treatments for malaria are currently lacking, and the clinical application of sickle cell traits remains unexplored. Objective: To establish the correlation between malaria and sickle cells and comprehensively understand the mechanisms through which sickle cells influence malaria. Method: This study was conducted by searching PubMed and CNKI for studies published within the last decade concerning the impact of sickle cell trait on malaria incidence, mortality, and morbidity in Africa. Data were meticulously extracted, analyzed, and synthesized to assess the protective role of SCT against malaria. Results: A total of 509 studies were found in the literature, of which 11 met the inclusion criteria and were selected for detailed analysis. The findings from these studies consistently indicate that sickle cell trait is associated with reduced incidence of malaria, as well as lower mortality and morbidity rates among affected individuals. These protective effects suggest potential new targets for malaria intervention and control strategies. Conclusion: Malaria threatens the population in Africa, causing substantial harm to individuals and communities. A comprehensive understanding of the effects of sickle cells on malaria and their mechanisms is necessary for the development of effective treatment and prevention programs.