Research Progress of Traditional Chinese Medicine in Non-small Cell Lung Cancer

Authors

  • Olivia Qi

DOI:

https://doi.org/10.54097/6svs6a75

Keywords:

Non-small cell lung cancer (NSCLC), Traditional Chinese medicine (TCM), Pharmacological mechanisms.

Abstract

This paper provides an in-depth look at the application of Chinese medicine in the treatment of non-small cell lung cancer (NSCLC) and its potential pharmacological mechanisms. NSCLC is one of the most common malignant tumors in the world, and despite the continuous progress of modern medical treatment, the quality of life and survival rate of patients still need to be improved. Traditional Chinese medicine (TCM), with its unique treatment concepts and methods, has shown potential in individualizing treatment and reducing side effects. Based on the basic theory of TCM, this paper expounds the etiology and pathogenesis of NSCLC in TCM, as well as the strategies of treating NSCLC in TCM, including fuzheng and dispelling evil, strengthening qi and reducing side effects. In particular, several commonly used TCM prescriptions, such as Liushenzi Decoction, Buzhong Yiqi Decoction, Shashen Madong Decoction, Baihe Gujin Decoction, etc. are mentioned, which can help to improve the symptoms and quality of life of NSCLC patients by promoting qi and Yin, clearing heat and eliminating phlegm, and strengthening the normal cultivation. In addition, the article also analyzed the main components of TCM, such as polysaccharides, alkaloids, flavonoids, etc., and their anti-tumor mechanisms, including immune regulation, antioxidant, direct anti-tumor effects. TCM is expected to play a more important role in the comprehensive treatment of NSCLC.

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References

[1] Hu, X.W., Luo, Y.B. Research progress of traditional Chinese medicine in treating non-small cell lung cancer. Guangming Chinese Medicine, 2024, 39(10): 2108-2110. (in Chinese)

[2] Li, W., Zhang, Q., Sun, J. The role of the PI3K/Akt signaling pathway in lung cancer and its therapeutic implications. Current Cancer Drug Targets, 2021, 21(5): 357-365.

[3] Zhu, H.R., et al. A brief analysis on the balance of Yin nourishing and phlegm-eliminating treatment in the treatment of advanced lung cancer. Global Chinese Medicine, 2024: 1-6.

[4] Chinese Anti-Cancer Association Lung Cancer Professional Committee. Guidelines for the treatment of non-small cell lung cancer with integrated Chinese and Western medicine. China Traditional Chinese Medicine Press, 2018.

[5] Li, X., Zhang, L. Ganoderma lucidum polysaccharides induce apoptosis in human lung cancer cells through the PI3K/Akt signaling pathway. Cancer Biotherapy & Radiopharmaceuticals, 2016, 31(7): 213-221.

[6] Chang, X., Feng, X., Du, M., Li, S., Wang, J., Wang, Y., Liu, P. Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy. Frontiers in Pharmacology, 2023, 14: 1194861.

[7] Liu, J., Zhang, X., Wang, X. Astragalus polysaccharides inhibit the growth of lung cancer cells by enhancing the immune response and inducing apoptosis. Molecular Medicine Reports, 2015, 11(5): 3806-3814.

[8] Wang, L., Zhang, X., Li, Q. Berberine inhibits non-small cell lung cancer cell growth and metastasis through modulation of PI3K/Akt and p53 pathways. Journal of Cellular Biochemistry, 2015, 116(12): 2727-2737.

[9] Li, Y., Wang, Y., Chen, H. Pinellia ternata alkaloid inhibits non-small cell lung cancer cell proliferation and invasion through cell cycle arrest and apoptosis induction. Molecular Medicine Reports, 2017, 16(6): 7417-7423.

[10] Liu, X., Zhang, L., Xu, Z. Matrine inhibits non-small cell lung cancer growth and metastasis by regulating the PI3K/Akt and NF-κB signaling pathways. Molecular Medicine Reports, 2015, 12(5): 6654-6660.

[11] Zhao, H., Li, W., Xu, M. Astragaloside IV inhibits non-small cell lung cancer progression through modulation of apoptosis and oxidative stress. Journal of Ethnopharmacology, 2016, 194: 108-117.

[12] Wu, W., Li, C., Yang, X. Eugenol inhibits non-small cell lung cancer progression by modulating NF-κB and MAPK signaling pathways. Cancer Letters, 2019, 442: 352-361.

[13] Wang, X., Liu, Q., Zhang, R. Diphyllin induces apoptosis in human lung cancer cells through the p53 signaling pathway. Phytotherapy Research, 2017, 31(4): 589-596.

[14] Yang, C., He, J., Zhang, Z. Induction of apoptosis by Oldenlandia diffusa in human cancer cells and its underlying mechanisms. Cancer Letters, 2018, 418: 206-213.

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Published

24-12-2024

How to Cite

Qi, O. (2024). Research Progress of Traditional Chinese Medicine in Non-small Cell Lung Cancer. Highlights in Science, Engineering and Technology, 123, 369-375. https://doi.org/10.54097/6svs6a75