Delivery of mRNA Vaccine and its Application for COVID-19

Haozhen Chen

doi:10.54097/tqqk4h91

Authors

Haozhen Chen

DOI:

https://doi.org/10.54097/tqqk4h91

Keywords:

mRNA vaccine, LNP, application.

Abstract

mRNA vaccine has potential to bring a revolutionary change to conventional vaccines due to its high eﬃcacy, minimal risk proﬁle, less time needed for development, and potential to be manufactured substantially. This innovation comes to spotlight as it successfully demonstrated its capacity to treat severe pandemic like COVID-19. Over decades of research on mRNA vaccine, a crucial focus has been the eﬃcient delivery of mRNA vaccines into the cytosol to facilitate protein synthesis, and thus several diﬀerent methods of mRNA delivery have been developed. This passage reviews ways of mRNA delivery, especially lipid-based nanoparticle (LNP) and its application in treating COVID-19.

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References

[1] Chunxi Zeng, Chengxiang Zhang, Patrick G. Walker, and Yizhou Dong. Formulation and Delivery Technologies for mRNA Vaccines (2020).

[2] Michael D. Buschmann, Manuel J. Carrasco, Suman Alishetty, Mikell Paige, Mohamad Gabriel Alameh, and and Drew Weissman. Nanomaterial Delivery Systems for mRNA Vaccines (2021).

[3] Norbert Pardi, Michael J. Hogan, Frederick W. Porter and Drew Weissman. mRNA Vaccines—A New Era in Vaccinology (2018).

[4] Enyue Fang, Xiaohui Liu, Miao Li, Zelun Zhang, Lifang Song, Baiyu Zhu, Xiaohong Wu, Jingjing Liu, Danhua Zhao, Yuhua Li. Advances in COVID-19 mRNA vaccine development (2022).

[5] Rumiana Tenchov, Robert Bird, Allison E. Curtze, and Qiongqiong Zhou. Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement (2021).

[6] Sivakumar Ramachandran, Soumya Ranjan Satapathy, Tathagata Dutta. Delivery Strategies for mRNA Vaccines (202).