Self-assembly of pH-responsive Prodrugs for Effective Antitumor Therapy
DOI:
https://doi.org/10.54097/hset.v36i.5673Keywords:
doxorubicin; pH-responsive; prodrug; polymeric nanoparticles.Abstract
A novel class of endosomal pH-responsive micellar nanoparticles was created by employing the self-assembly of an amphiphilic poly(ethylene glycol)-Schiff-doxorubicin (PEG-Schiff-DOX) drug. Under normal circumstances, these nanoparticles had excellent storage durability for at least 7 days, but they immediately disintegrated in a mildly acidic environment. Furthermore, a planned drug release behavior was seen, taking advantage of the different drug release mechanisms, which could lead to a higher intracellular drug concentration and longer action duration. The nanoparticles outperformed free DOX in anticancer efficacy against Hela cells, according to CCK-8 assays. Therefore, these prodrug-based nanomedicines hold significant promise for developing translational DOX tumor therapy formulations.
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