Insight into the Pathogenesis, Diagnosis, and Current Strategies of Diabetic Cardiomyopathy

Abstract

The concept of diabetes cardiomyopathy (DCM) was first introduced by rubler and his colleagues. DCM refers to the adverse myocardial structure which is associate with diabetes. The primary pathogenesis of diabetes mellitus, insulin resistance, is also a predisposing factor for cardiovascular disease. In addition, diabetic disease is also associated with abnormal cytosolic calcium regulation, systolic dysfunction, cardiac remodeling, myocardial stiffness, and hypertrophy. Diabetic patients are normally affected by cardiovascular disorders. Several diagnosis approaches could be used in DCM, including echocardiography, magnetic resonance imaging (MRI) and nuclear imaging. Given the broad influence and complex mechanism of DCM, effective therapies are urgently needed. Current treatments for DCM are mainly target several critical proteins. Lifestyle interventions for patients with DCM are beneficial as well. DCM has been known by researchers for 50 years, but the relevant signaling pathways and targeted therapies still need further investigation.