How do Spike Proteins of SARS-CoV-2 and ACE2 Make Covid-19 Pandemic Inevitable?
DOI:
https://doi.org/10.54097/hset.v36i.6168Keywords:
SARS-CoV-2, Spike Protein, ACE2, Angiotensin.Abstract
People's lives throughout the world have been impacted by the Covid-19 epidemic. There are numerous viruses that can cause human disease, so what exactly made SARS-CoV-2 different from others and caused a quite severe impact? Unlike other common viruses, SARS-CoV-2 is highly infectious and virulent. The most crucial surface protein of coronaviruses is the spike (S) protein, and it is the structure that is responsible for binding human cells and infecting them. And the mutation of the S protein that gives the virus higher affinity with the host receptor might be a possible explanation for its strong infectiousness. Angiotensin-converting enzyme 2 (ACE2) receptors are the sites on cell surfaces where SARS-CoV-2 binds, it is an important enzyme in the human body that has various regulatory roles. This paper will also discuss their structure and functions, as well as the possibility of treating ACE2 proteins as a target to diminish the infection of SARS-CoV-2.
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