EGFR: an Overview and Mutation on Lung Cancer

Abstract

Cancer is a popular and well-known disease all over the world. It is a genetic disease that mutations occur on patients’ genome and cause cells to proliferate uncontrollably and start to invade surrounding tissues which is not commonly seen on normal cells and tissues. It is a common cause of death in the world.  In 2020, the number of people died because of cancer is 10 million. Among these deaths, lung cancer account for 2.21 million cases which is the second largest group of all cancer types. Among all lung cancer types, non-small cell lung carcinoma (NSCLC) constitutes around 80 percent lung cancer. EGFR is a gene that mutation on it is often found within the genome of NSCLC patients. According to a report, 30466 patients among 115815 NSCLC patients are found to have EGFR mutation in order to provide suggestion for patients with mutation on EGFR to have a better therapeutic effect, learning the function of a gene and its impact on metastasis is necessary. This review intended to give an overview on the EGFR (epidermal growth factor receptor) which mutation on it is often seen on lung Cancer.