Schiff-Linked Pegylated Doxorubicin Prodrugs Forming Ph-Responsive Nanoparticles with High Drug Loading Capacity and Improved Drug Consignment
DOI:
https://doi.org/10.54097/hset.v45i.7285Keywords:
Doxorubicin, nanopolymers, pH-responsive, anticancer drugs.Abstract
A new pH-responsive micellar nanopolymers was manufactured through self-assembly of PEG-Schiff-DOX prodrug in aqueous solutions. These nanoparticles show good biocompatibility and storage fixity for more than one week under normal conditions, and the advantage of rapid degradation under weak acid conditions. Under this circumstance, the in vitro experiments show that compared with the dissociative DOX drug, the PEG-Schiff-DOX nanoparticles exhibit the lower cytotoxicity and higher anti-tumor activity against the Hela tumor cells, indicating its great potential in various nanomedicine fields.
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