Optimization and Quality Assessment of Baihu Decoction Granules Using Traditional Concepts and Modern Techniques

Abstract

 Baihu Decoction is a classical traditional Chinese medicine (TCM) formula widely used in the treatment of febrile and inflammatory conditions due to its significant heat-clearing and fluid-generating properties. This study systematically optimized the extraction and granule preparation process of Baihu Decoction by integrating traditional formulation theory with modern pharmaceutical technologies. A multi-step extraction and granulation protocol was developed, combining traditional decoction, concentration, and carboxymethyl chitosan flocculation with modern granulation techniques. Key bioactive constituents, especially from Anemarrhena asphodeloides, were qualitatively and quantitatively analyzed using Thin-Layer Chromatography (TLC) under Total Ion Chromatogram (TIC) conditions and High-Performance Ion Chromatography (HPIC), respectively. The results confirmed the stability and consistency of the granule formulation, demonstrating improved extract concentration and potential for standardized production. While the study effectively improves preparation efficiency and ingredient retention, it is limited by the lack of in vivo pharmacological and clinical efficacy evaluation. Future work should focus on pharmacodynamic studies, toxicity assessment, and industrial-scale process validation to support clinical application and promote the modernization and internationalization of traditional Chinese medicine.