Progress and Prospect of Dscam Gene in Drosophila Immunity
DOI:
https://doi.org/10.54097/t7tcq290Keywords:
Drosophila, Drosophila Immunity, Dscam GeneAbstract
The cell adhesion molecule (Dscam) gene in Down syndrome is an extraordinary example of diversity: by combining alternative splicing exons, thousands of subtypes can be generated from just one gene. So far, this diversity of the gene has only been found in insects and crustaceans, and the basic part of neural connections has been well characterized as Drosophila melanogaster. More than a decade ago, evidence from Drosophila melanogaster indicated that the Dscam gene is involved in insect immune defense. However, we are still far from fully understanding the functions of Dscam in parasites and pathogens, as well as its full correlation with the immune system. In this article, we first briefly introduce the immune mechanism of fruit flies and the current research status of Dscam. Finally, the future research prospects of Dscam are summarized and proposed, with the aim of providing a multi perspective perspective to further study the relationship between this gene and immune defense in detail.
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References
Yamakawa K, Huot YK, Haendelt MA, Hubert R, Chen XN, Lyons GE, et al. DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet (1998) 7:227–37. 10.1093/hmg/7.2.227 .
Watson FL, Püttmann-Holgado R, Thomas F, Lamar DL, Hughes M, Kondo M, Rebel VI, Schmucker D. Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005;309:1874–1878.
Armitage SAO, Brites D. The immune-related roles and the evolutionary history of Dscam in arthropods. In: Malagoli D, editor. The Evolution of the Immune System. London, San Diego, Cambridge, Oxford: Elsevier; (2016). p. 241–74.
Pizzano S, Sterne GR, Veling MW, Xu LA, Hergenreder T, Ye B. The Drosophila homolog of APP promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes. Dis Model Mech. 2023 Sep 1;16 (9): dmm049725. doi: 10.1242/dmm.049725. Epub 2023 Sep 15. PMID: 37712356.
Rosetto M., Engstrom Y., Baldari C. T., Telford J. L., Hultmark D. (1995). Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line. Biochem. Biophys. Res. Commun. 209, 111–116. 10.1006/ bbrc. 1995.1477 .
Mahanta DK, Bhoi TK, Komal J, Samal I, Nikhil RM, Paschapur AU, Singh G, Kumar PVD, Desai HR, Ahmad MA, Singh PP, Majhi PK, Mukherjee U, Singh P, Saini V, Shahanaz, Srinivasa N, Yele Y. Insect-pathogen crosstalk and the cellular-molecular mechanisms of insect immunity: uncovering the underlying signaling pathways and immune regulatory function of non-coding RNAs. Front Immunol. 2023 Aug 24;14:1169152. doi: 10.3389/fimmu.2023.1169152.
Lemaitre B., HoffmannJ. (2007). The host defense of Drosophila melanogaster. Annu. Rev. Immunol. 25, 697–743. 10.1146/annurev.immunol.25.022106.141615.
Li Guohui, Zhou Qian, Hu Chaoyang, etc. Progress in the molecular mechanism of innate immunity in Drosophila [J]. Life Science Research, 2015,19 (06): 559-564.
Kounatidis I., Ligoxygakis P. (2012). Drosophila as a model system to unravel the layers of innate immunity to infection. Open Biol. 2:120075. 10.1098/rsob.120075.
Younes S, Al-Sulaiti A, Nasser EAA, Najjar H, Kamareddine L. Drosophila as a Model Organism in Host-Pathogen Interaction Studies. Front Cell Infect Microbiol. 2020 Jun 23;10:214.
Armitage SA, Freiburg RY, Kurtz J, Bravo IG. The evolution of Dscam genes across the arthropods. BMC Evol Biol. 2012 Apr 13;12:53.
Neves G, Zucker J, Daly M, Chess A. Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat Genet (2004) 36:240–6. 10.1038/ng1299.
Dong Y, Taylor HE, Dimopoulos G. AgDscam, a hypervariable immunoglobulin domain-containing receptor of the Anopheles gambiae innate immune system. PLoS Biol (2006) 4:e229. 10.1371/journal.pbio.0040229.
Guo Pengjuan. Functional studies of the diversity of Dscam1 mutually exclusive alternative splice variants in Drosophila melanogaster [D]. Zhejiang University, 2022.
Yu H, Yang J, Wang J, Huang Y, Lee T. Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. J Neurosci (2009) 29: 1904–14. 10.1523/ JNE UROSCI. 5743-08.2009 .
Janeway C, Travers P, Walport M, Shlomchik M. Immunobiology. 6th ed New York: Garland Science; (2005).
Ng TH, Chiang YA, Yeh YC, Wang HC. Review of Dscam-mediated immunity in shrimp and other arthropods. Dev Comp Immunol (2014) 46:129–38. 10.1016/j.
Armitage SAO, Brites D. The immune-related roles and the evolutionary history of Dscam in arthropods. In: Malagoli D, editor. The Evolution of the Immune System. London, San Diego, Cambridge, Oxford: Elsevier; (2016). p. 241–74.
XiaoLi Z, GuoQing S, XiaoNa Z, et al. Immune functions of the Dscam extracellular variable region in Chinese mitten crab.[J]. Fish & shellfish immunology,2023,138.
Shi Jilong. Functional study of the variable Ig3 domain diversity of Drosophila Dscam1 [D]. Zhejiang University, 2022.
Armitage SAO, Kurtz J, Brites D, Dong Y, Du Pasquier L, Wang HC. Dscam1 in Pancrustacean Immunity: Current Status and a Look to the Future. Front Immunol. 2017 Jun 9;8:662.
Bouallegui Y. A Comprehensive Review on Crustaceans' Immune System with a Focus on Freshwater Crayfish in Relation to Crayfish Plague Disease. Front Immunol. 2021 May 13;12:667787.
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