Toxicity Evaluation of Honghe Fujie lotion Against Candida Albicans in Vitro and in Vivo

Qing He; Zihao Liu; Shuai Wang

doi:10.54097/5vnkwq82

Authors

Qing He
Zihao Liu
Shuai Wang

DOI:

https://doi.org/10.54097/5vnkwq82

Keywords:

Honghe Fujie Lotion, Candida Albicans, Mycotic Vaginitis

Abstract

Mycotic vaginitis is a common vulvovaginitis in gynecology, with a high incidence rate, which is mainly caused by candida albicans infection. Honghe Fujie lotion is mainly used to treat fungal vaginitis caused by C. albicans, but its antibacterial mechanism against C. albicans in vitro and in vivo is still unclear. Here, we found that Honghe Fujie lotion can significantly inhibit the formation of C. albicans ATCC (American Type Culture Collection) 10231 colony, and its inhibitory effect on colony formation continued to increase with increasing drug concentration. The group treated with Honghe Fujie lotion showed a dose-dependent decrease in vaginal mucosal damage in VVC (vulvovaginal candidiasis) model rats, hindered the infiltration and diffusion of inflammatory cells, and exhibited similar conditions to the positive control drug Amphotericin B group. In summary, our data indicated that Honghe Fujie lotion can significantly reduce the formation of C. albicans in the vagina of VVC model rats, protected the vaginal mucosal tissue of rats, hindered the infiltration and diffusion of inflammatory cells, and improved the vaginal infection status of VVC model rats.

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