Preliminary study on angiogenesis and functional evaluation of benign adrenal pheochromocytoma vessels

Changsheng Yuan; Huichuan Zhao; Zhigang Huang; Hui Pan; Shaoping Cheng

doi:10.54097/ijbls.v1i1.2270

Authors

Changsheng Yuan
Huichuan Zhao
Zhigang Huang
Hui Pan
Shaoping Cheng

DOI:

https://doi.org/10.54097/ijbls.v1i1.2270

Keywords:

Pheochromocytoma, Angiogenesis, MVD, VEGF, Function

Abstract

Objective: To study the relationship between the pheochromacytomas’ MVD and VEGF expression which are two indexes of angiogenesis, and analyze the difference of MVD and VEGF expression in different groups of pheochromocytomas with the purpose of correlating pheochromocytoma’s function and angiogensis. Methods From June 2009 to December 2015, thirty-one patients histologically diagnosed as benign pheochromocytoma were divided into two groups according to the length of preparing time before operation(group 1≦2 weeks, group 2>2 weeks), and eight normal adrenal glands as the control group. The MVD and VEGF expression of all the pheochromocytomas and normal adrenal glands were evaluated, with the purpose of correlating the MVD and VEGF expression and analyzing the difference among of two groups of pheochromocytomas and normal adrenal glands. The tumors’ diameter, intratumoral necrosis and the patients’ urine VMA were also analyzed with MVD and VEGF expression. Results :1) The mean value of MVD in group 1 is 50.2±15.4 per HP, and less than the group 2 with the mean value 69.5±3.8 per HP(p<0.05), but more than the normal adrenal glands with the mean value 35.1±3.4 per HP(p<0.05). There is no MVD mean value difference between groups divided according to tumors’ diameter, intratumoral necrosis and the patients’ urine VMA. There is 30.8% high VEGF expression in group 1 less than group 2 with 77.8%(p<0.05), and there no high VEGF expression rate difference between groups divided according to tumors’ diameter, intratumoral necrosis and the patients’ urine VMA; The MVD correlates with VEGF expression in pheochromocytomas (r=0.545, p<0.05). Conclusion :1) The function of pheochromocytoma maybe correlate with the angiogenesis. 2) The angiogenesis of pheochromocytoma was more than that of the normal adrenal gland. 3)There are no correlation with the angiogenesis and tumor’s diameter, intratumoral necrosis and the patients’ urine VMA in this study.

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