Research Progress of SLC38A5 in Disease Progression
DOI:
https://doi.org/10.54097/j5b98n70Keywords:
SLC38A5, Membrane Protein, Amino Acids, Disease ProgressionAbstract
The family of membrane proteins known as amino acid transporters (AAT) is responsible for regulating the transmembrane transportation of amino acids. Featuring 458 transporters grouped into 65 families, the solute carrier (SLC) superfamily is the largest family of transport proteins. Every family plays a crucial part in cellular physiology and exhibits unique substrate specificity and tissue distribution aspects. In order to preserve intracellular metabolic homeostasis, they control the absorption and efflux of crucial molecules such as ions, glucose, fatty acids, and amino acids. They are also essential for differentiation, cell division, and signal transmission. SLC38A5 (also called SNAT5, SN2), a member of the SLC family, has steadily gained attention in recent years as research has become more thorough. The X chromosome contains the gene that codes for SLC38A5, which is a sodium-dependent neutral amino acid transporter with 11 transmembrane domains. It makes it easier for sodium ions and amino acids to move across the membrane simultaneously. It is involved in a variety of cellular processes, and illnesses like cancer, neurodegenerative diseases, and metabolic disorders are intimately linked to its abnormal expression or malfunction. Its distinct function in the development of disease has drawn more and more attention. This article examines new research on SLC38A5 in immunology, metabolic disorders, cancer, and neurodegenerative diseases that was found using databases like Web of Science and PubMed. We provide an overview of SLC38A5 biology in this review, focusing on new discoveries on its function in the development of disease. The structure, distribution, physiological activities, and properties of SLC38A5 are all covered in this discussion, along with its pathogenic roles and potential therapies in particular diseases.
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