Regional Differences in UTI Microbiome Studies
DOI:
https://doi.org/10.54097/4kgce751Keywords:
Urinary Tract Infection (UTI), Probiotic Treatment Methods, NGS Technology, A Bacterial Colonization of the Bladder, Regional Differences in Microbiome ResearchAbstract
Urinary Tract Infection (UTI) is a common condition often expressed as a bacterial colonization of the bladder that in severe conditions extends to associated structures in the urinary system. The topic of recurrent UTI and antibiotic resistance has prompted several researchers to focus on the relationship gut and urinary microbiome have with recurrent UTI, searching for potential cures to antibiotic-resistant UTIs from the probiotic approach. This study aimed to find regional differences in microbiome studies, including the taxonomies in microbiomes across regions and their relationships to the local UTI conditions. The study reviewed data and findings of two iconic studies, Choi et al. and Huang et al., to examine how their findings would contribute to future research on probiotic treatments and the role of the gut-bladder axis in UTI. It found out that many identified UTI-causing pathogens are opportunistic species, whose relationships with the host are complicated by weakened immune systems, gut-bladder proximity and genetic plasticity. Additionally, the study pointed out several advantages of NGS technology that provide promising insight into microbiome taxonomies previously unreached by culturing methods. It identified several species as potential UTI-curing probiotics, though their wide applications were cautioned. Further research on UTI microbiome across regions and their effects on the local conditions is still warranted.
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