The Research Progress and Clinical Application of Chimeric Antigen Receptor T-Cell Therapy

Abstract

Immunotherapy, as an emerging method for tumor therapy, which offers numerous hopes for patients with tumor. Among these, Chimeric antigen receptor (CAR) T-cell therapy is one of the most remarkable ones, which have achieved huge progress in cancer therapy and with a compelling prospect. CAR T is a kind of T cells that mediated by antigen receptor, transmembrane domain, activation domain; rebuilt by viral vector like lentivirus, retrovirus, non-viral vector such as mRNA, DNA etcetera and modified by immunosuppressive microenvironment. In this article, I at first reviewed classical CAR T development, second, I analyzed non-viral CAR T, third I discussed in vivo editing system of CAR T, at last I look forward to the future prospects of CAR T therapy. This review wishes to offer some ideas and appreciates for CAR T therapy by analyzing classic CAR T, discussing in vitro CAR T cells, absorbing in vivo CAR T therapy.