Effects of Endovascular Interventional Therapy at Different Stages on Blood Pressure and Cerebral Blood Flow Perfusion in Patients with Ruptured Hunt-Hess High-Grade Intracranial Aneurysms

Renhua Xie; Weiwu Zhang; Yuting Chen; Xiaotian Li; Qimin Wang; Xuan Zhou

doi:10.54097/ktme1s34

Authors

Renhua Xie
Weiwu Zhang
Yuting Chen
Xiaotian Li
Qimin Wang
Xuan Zhou

DOI:

https://doi.org/10.54097/ktme1s34

Keywords:

Hunt-Hess high-grade, Ruptured Intracranial Aneurysm, Blood Pressure, Cerebral Blood Flow Perfusion

Abstract

Objective To investigate the effects of endovascular interventional therapy at different stages on blood pressure and cerebral blood flow perfusion in patients with ruptured Hunt-Hess high-grade intracranial aneurysms. Methods The clinical data of 137 patients with ruptured Hunt-Hess high-grade intracranial aneurysms admitted to the hospital from January 2022 to January 2024 were retrospectively analyzed. Patients were grouped according to the timing of endovascular intervention. Patients treated within 48 hours of onset were included in the observation group (n=75), while those treated between 48 and 96 hours after onset were assigned to the control group (n=62). The changes of blood pressure during operation and compared to preoperative values were analyzed in the two groups, postoperative cerebral blood flow perfusion [Cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT)]. The incidence of complications within 6 months after surgery was compared between the two groups. Results Intraoperative hemodynamic stability in the observation group were lower than those in the control group (P<0.05). Postoperative CBF and CBV were higher than before operation in both groups. And TTP and MTT were shorter than before surgery (P<0.05). However, there was no statistically significant differences between groups (P>0.05). The incidence of complications in the observation group was lower than that in the control group (P<0.05). Conclusion The earlier vascular interventional treatment is performed, the more conducive to stabilizing intraoperative blood pressure and reducing the risk of postoperative complications in patients with Hunt-Hess high-grade ruptured intracranial aneurysms.

Downloads

Download data is not yet available.

References

[1] Rice-Canetto TE, Ueno A, Whitney E, et al. A Review of the Current Literature on Cerebral Aneurysms[J]. Cureus, 2025, 17(3): e80223.

[2] Gaudino C, Navone SE, Da Ros V, et al. Incidence of intra-procedural complications according to the timing of endovascular treatment in ruptured intracranial aneurysms[J]. Front Neurol, 2023, 13: 1096651.

[3] Ohbuchi H, Kasuya H, Hagiwara S, et al. Appropriate treatment within 13 hours after onset may improve outcome in patients with high-grade aneurysmal subarachnoid hemorrhage [J]. Clin Neurol Neurosurg, 2023, 230: 107776.

[4] Hostettler IC, Lange N, Schwendinger N, et al. Duration between aneurysm rupture and treatment and its association with outcome in aneurysmal subarachnoid haemorrhage[J]. Sci Rep, 2023, 13(1): 1527.

[5] Li XY, Li CH, Wang JW, et al. Safety and Efficacy of Endovascular Embolization of Ruptured Intracranial Aneurysms within 72 hours of Subarachnoid Hemorrhage[J]. J Neurol Surg A Cent Eur Neurosurg, 2022 ,83(3):265-274.

[6] Etminan N, Macdonald RL. Neurovascular disease, diagnosis, and therapy: Subarachnoid hemorrhage and cerebral vasospasm [J]. Handb Clin Neurol, 2021,176:135-169.