Correlation Analysis of Clinical Factors for Deep Vein Thrombosis After Total Hip Arthroplasty
DOI:
https://doi.org/10.54097/hg64sj44Keywords:
Hip Replacement, Deep Vein Thrombosis, Risk Factors, Cardiovascular DiseaseAbstract
Deep vein thrombosis (DVT) after hip replacement surgery is a severe complication affecting patient recovery, and its formation is the result of multiple factors acting together. This article reviews the correlation between four major factors: blood lipids, blood glucose, blood pressure, and smoking, and the occurrence of DVT. Studies have shown that dyslipidemia (especially elevated triglycerides) and diabetes are significant independent risk factors for DVT, and there is a dose-response relationship between hyperglycemia and thrombosis risk. Although hypertension increases the risk of thrombosis, its independent predictive value in a multifactorial model remains controversial and may exist more as a background factor. Smoking demonstrates a clear dose-dependent hazard, and perioperative smoking cessation is crucial for reducing the risk of complications. Future research should further focus on the interaction of multiple risk factors and the establishment of a standardized risk assessment system.
Downloads
References
[1] Doggen C J M, Smith N L, Lemaitre R N, et al. Serum lipid levels and the risk of venous thrombosis[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2004, 24(10): 1970-1975.
[2] Bhatt D L, Steg P G, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia[J]. New England Journal of Medicine, 2019, 380(1): 11-22.
[3] Das Pradhan A, Glynn R J, Fruchart J C, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk[J]. New England Journal of Medicine, 2022, 387(21): 1923-1934.
[4] Criqui M H, Heiss G, Cohn R, et al. Plasma triglyceride level and mortality from coronary heart disease[J]. New England Journal of Medicine, 1993, 328(17): 1220-1225.
[5] Nowak-Göttl U, Junker R, Hartmeier M, et al. Increased lipoprotein (a) is an important risk factor for venous thromboembolism in childhood[J]. Circulation, 1999, 100(7): 743-748.
[6] Han Zhe, Cao Dongdong, Sun Xiang, Han Chao, Xie Mengqi, Dong Qiang. Risk Factors of Deep Venous Thrombosis After Hip Replacement Surgery: A Systematic Review and Meta-Analysis [J]. Chinese Journal of Laboratory Diagnosis, 2023, 27(04): 379-389.
[7] Huang Y, Ge H, Wang X, et al. Association between blood lipid levels and lower extremity deep venous thrombosis: a population-based cohort study[J]. Clinical and Applied Thrombosis/Hemostasis, 2022, 28: 10760296221121282.
[8] Lin Lingying, Zeng Liping, Chen Lingxiang, Tang Meixiu. Influencing factors of deep vein thrombosis in patients after total hip arthroplasty [J]. Guangxi Medical Journal, 2020, 42(16): 2108-2111+2135.
[9] Yang Yuchun, Wang Xiaohai, Zhang Yongmei, Dai Tijun. Incidence and risk factors of deep venous thrombosis in the lower extremities after total hip replacement under general anesthesia in elderly patients [J]. Journal of Regional Anatomy and Operative Surgery, 2019, 28(02): 108-111.
[10] Zhong Huan, Zheng Hong, Chen Jiming, Wu Shaoke, Tan Hongchang. Study on the related factors of deep vein thrombosis after total hip arthroplasty [J]. Chinese Journal of Laboratory Diagnosis, 2012, 16(06): 1058-1061.
[11] Hang L, Haibier A, Kayierhan A, et al. Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty[J]. BMC Surgery, 2024, 24(1): 256.
[12] Wang S, Zhao Y. Diabetes mellitus and the incidence of deep vein thrombosis after total knee arthroplasty: a retrospective study[J]. The Journal of Arthroplasty, 2013, 28(4): 595-597.
[13] Zhao Z, Wang S, Ma W, et al. Diabetes mellitus increases the incidence of deep vein thrombosis after total knee arthroplasty[J]. Archives of Orthopaedic and Trauma Surgery, 2014, 134(1): 79-83.
[14] Yang G, Meng F, Liu Y, et al. Diabetes mellitus and risk of deep vein thrombosis after total knee replacement: a meta-analysis of cohort studies[J]. International Journal of Clinical and Experimental Medicine, 2015, 8(6): 9086.
[15] Bolognesi M P, Marchant Jr M H, Viens N A, et al. The impact of diabetes on perioperative patient outcomes after total hip and total knee arthroplasty in the United States[J]. The Journal of Arthroplasty, 2008, 23(6): 92-98.
[16] Qin W, Huang X, Yang H, et al. The Influence of Diabetes Mellitus on Patients Undergoing Primary Total Lower Extremity Arthroplasty: A Systematic Review and Meta‐Analysis[J]. BioMed Research International, 2020, 2020(1): 6661691.
[17] Deng W, Huo L, Yuan Q, et al. Risk factors for venous thromboembolism in patients with diabetes undergoing joint arthroplasty[J]. BMC Musculoskeletal Disorders, 2021, 22(1): 608.
[18] Yao W, Tang W, Wang W, et al. Association between hyperglycemia on admission and preoperative deep venous thrombosis in patients with femoral neck fractures[J]. BMC Musculoskeletal Disorders, 2022, 23(1): 899.
[19] Ye Mao, Chang Ning, Liang Miaomiao, Guo Lan, Li Jia, Zhang Bo. Analysis of influencing factors of deep venous thrombosis in lower limbs of elderly patients undergoing hip replacement surgery [J]. Journal of Practical Orthopedics, 2020, 26(01): 4-7.
[20] Jiang Linlin, Zhao Qingchun. Analysis of influencing factors of deep venous thrombosis in lower limbs after total hip arthroplasty [J]. Journal of Clinical Military Medicine, 2018, 46(09): 1051-1054.
[21] Guo Yunyun. Logistic Regression Analysis of Deep Venous Thrombosis in Patients After Total Hip Replacement [J]. Chinese Journal of School Medicine, 2015, 29(01): 45-46.
[22] Anderson Jr F A, Spencer F A. Risk factors for venous thromboembolism[J]. Circulation, 2003, 107(23_suppl_1): I-9-I-16.
[23] Ageno W, Becattini C, Brighton T, et al. Cardiovascular risk factors and venous thromboembolism: a meta-analysis[J]. Circulation, 2008, 117(1): 93-102.
[24] Huang L, Li J, Jiang Y. Association between hypertension and deep vein thrombosis after orthopedic surgery: a meta-analysis[J]. European Journal of Medical Research, 2016, 21(1): 13.
[25] Macdonald C J, Madika A L, Lajous M, et al. Association between cardiovascular risk-factors and venous thromboembolism in a large longitudinal study of French women[J]. Thrombosis Journal, 2021, 19(1): 58.
[26] Huang W, Hu W, Lei B, et al. Risk factors for venous thrombosis after hip arthroplasty: a meta-analysis[J]. BMC Musculoskeletal Disorders, 2025, 26(1): 508.
[27] Hang L, Haibier A, Kayierhan A, et al. Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty[J]. BMC Surgery, 2024, 24(1): 256.
[28] Liu Xiaolong, Zhang Liang, Zhang Shijie, Li Zhuangyan. Risk Factors and Construction of Risk Prediction Model for Deep Venous Thrombosis in Lower Extremities after Total Hip Arthroplasty [J]. Journal of Medical Forum, 2025, 46(09): 953-958.
[29] Fu Zhiqiang, Wang Wei, He Feixiong, Hong Shengkun, Zhou Weijun. Analysis of Risk Factors for Deep Venous Thrombosis in the Lower Extremities Following Total Hip Arthroplasty [J]. Zhejiang Practical Medicine, 2023, 28(03): 226-228+232.
[30] Zhang Cheng. Analysis of the incidence and influencing factors of deep vein thrombosis in patients after hip replacement surgery [J]. Medical Innovation in China, 2022, 19(19): 136-140.
[31] Hansson P O, Eriksson H, Welin L, et al. Smoking and abdominal obesity: risk factors for venous thromboembolism among middle-aged men: the study of men born in 1913[J]. Archives of Internal Medicine, 1999, 159(16): 1886-1890.
[32] Cheng Y J, Liu Z H, Yao F J, et al. Current and former smoking and risk for venous thromboembolism: a systematic review and meta-analysis[J]. PLoS Medicine, 2013, 10(9): e1001515.
[33] Singh J A, Schleck C, Harmsen W S, et al. Current tobacco use is associated with higher rates of implant revision and deep infection after total hip or knee arthroplasty: a prospective cohort study[J]. BMC Medicine, 2015, 13(1): 283.
[34] Singh J A. Smoking and outcomes after knee and hip arthroplasty: a systematic review[J]. The Journal of Rheumatology, 2011, 38(9): 1824-1834.
[35] Al-Nasser B. Influence of tobacco smoking on perioperative risk of venous thromboembolism[J]. Turkish Journal of Anaesthesiology and Reanimation, 2019, 48(1): 11.
[36] Zhou Zemin, Jin Wangyi, Yang Yang, Guo Kaijin, Zheng Xin, Zhang Xing. Analysis of influencing factors of deep venous thrombosis in lower limbs after total hip arthroplasty [J]. Journal of Xuzhou Medical University, 2025, 45(06): 412-418.
[37] Wang Zhiqiang. Analysis of Risk Factors for Deep Venous Thrombosis in Lower Limbs Following Hip Replacement Surgery [J]. Chinese Journal of Drugs and Clinical Practice, 2021, 21(12): 2072-2074.
[38] You Weifang. Research on Clustered Nursing Intervention for Deep Venous Thrombosis in Lower Limbs after Artificial Hip Replacement [D]. Yunnan College of Traditional Chinese Medicine, 2018.
[39] Liu Jun, Shen Fei, Huang Jihe. Analysis of Risk Factors for Deep Venous Thrombosis Following Total Hip Arthroplasty [J]. Journal of Kunming Medical University, 2012, 33(07): 84-87.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

