Uncovering of the Evolutionary Relationship of SARS-COV-2 by Analyzing 13 Genomic Sequences


  • Xingchen Liu




Compulsory isolation, Drug abstainer, Meaning in life, Relapse tendency.


The outbreak of acute respiratory disease caused by a novel coronavirus (SARS-CoV-2) is spreading rapidly around the world. However, the variation and evolution of this virus are still largely unknown. It is urgently necessary to predict the damages caused by this virus to humans in the future. Here, I provided the clues for the SARS-CoV-2 mutated prediction, drug treatment, morbidity, or infectivity through whole-genome analysis using different types of viruses. The 13 SARS-COV-2 genomic sequences were employed to be analyzed to look for their evolutionary relationship. I found that the spike protein in the SARS-CoV-2 had the most mutations than the other proteins, which suggested that spike protein plays a key role in the processing of viral infection and the evolution of the SARS-CoV-2. Moreover, 12 possible phosphorylation sites in spike protein were predicted indicating that these amino acids may have potential significance in viral pathogenesis. Together, our study may provide several novel clues for researchers to study the morbidity or infectivity of the virus and to find the strategies to control it in the near future.


SARS variants: https://www.who.int/zh/activities/tracking-SARS-CoV-2-variants; https://www.who.int/activities/tracking-SARS-CoV-2-variants

Kadam, S. B., Sukhramani, G. S., Bishnoi, P., Pable, A. A., & Barvkar, V. T. (2021). SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights. Journal of Basic Microbiology, 61(3), 180-202.

Grubaugh, N. D., Petrone, M. E., & Holmes, E. C. (2020). We shouldn’t worry when a virus mutates during disease outbreaks. Nature microbiology, 5(4), 529-530.

Herrera, N. G., Morano, N. C., Celikgil, A., Georgiev, G. I., Malonis, R. J., Lee, J. H., ... & Almo, S. C. (2020). Characterization of the SARS-CoV-2 S protein: biophysical, biochemical, structural, and antigenic analysis. ACS omega, 6(1), 85-102.

Yurkovetskiy, L., Wang, X., Pascal, K. E., Tomkins-Tinch, C., Nyalile, T. P., Wang, Y., ... & Luban, J. (2020). Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant. Cell, 183(3), 739-751.

Eaaswarkhanth, M., Al Madhoun, A., & Al-Mulla, F. (2020). Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality?. International Journal of Infectious Diseases, 96, 459-460.



26 July 2022

How to Cite

Liu, X. (2022). Uncovering of the Evolutionary Relationship of SARS-COV-2 by Analyzing 13 Genomic Sequences. International Journal of Education and Humanities, 3(3), 6–8. https://doi.org/10.54097/ijeh.v3i3.1000