Clinical Effect Analysis of the Combined Application of SGLT2i and ARNi in the Treatment of Patients with Atrial Fibrillation and Heart Failure in 2021-2022
DOI:
https://doi.org/10.54097/45889t69Keywords:
Atrial fibrillation; heart failure; SGLT2i; ARNi.Abstract
The purpose of this study was to evaluate the combination of SGLT2i (sodium-glucose cotransporter 2 inhibitor) and ARNi (angiotensin receptor enkephalin inhibitor) in patients with atrial fibrillation and heart failure. The study used a randomized controlled trial design with 100 patients divided into control and experimental groups receiving conventional anti-heart failure therapy and combination therapy, respectively. The primary endpoint events included cardiovascular death, hospitalization for heart failure, and emergency department visits due to atrial fibrillation, while the secondary endpoint events included heart rate, blood pressure, improvement in cardiac function, and quality of life score. Strict quality control standards were followed during data collection, and data were collected using standardized questionnaires, physical examinations, laboratory tests, and electrocardiogram. Data were analyzed using SPSS software, including descriptive statistics, chi-square test, t-test, and the Cox regression model. The results showed that the combination group showed a trend to the control group at both primary and secondary endpoints, indicating that the combination of SGLT2i and ARNi may help to improve the treatment effect and quality of life in patients with AF and heart failure. This study provides new therapeutic strategies in the clinic and provides valuable reference information for research in related fields. However, due to the small sample size and short study duration, future larger, long-term tracked studies are still needed to further validate the effect of the combination.
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Chen Yan, Cui Liuyi. Analysis of the clinical effect of simvastatin combined with trimetazidine in patients with coronary heart disease and heart failure [J]. Tianjin Pharmaceutical Science, 2023,35 (01): 47-49.
Zhang Jiequn, Zhang Tiemin. Analysis of the clinical effect of non-invasive ventilator treatment in patients with heart failure combined with respiratory failure [J]. Journal of Chronic Diseases, 2022,23 (02): 307-309.
Tursun Guri, Zhang Wei, AzGuri. Analysis of clinical effect of non-invasive ventilator in patients with heart failure with respiratory failure in intensive care unit [J]. Electronic Journal of Cardiovascular Diseases of Integrated Chinese and Western Medicine, 2021,9 (36): 22-24.
Zhang Liyan. Analysis of clinical effects of comprehensive treatment in patients with severe pregnancy hypertension [J]. Practical Electronic Journal of Gynecological Endocrinology, 2021,8 (33): 73-75.
Zhang Yan. Analysis of the clinical effect of sarkubacherevalsartan sodium in elderly patients with hypertension and chronic heart failure [J]. Electronic Journal of Integrated Chinese and Western Medicine, 2021,9 (31): 68-70.
Jiang Wenkang. Analysis of the clinical effect of non-invasive ventilator treatment in patients with ICU heart failure complicated with respiratory failure [J]. Rural Health in China, 2021,13 (05): 72 + 71.
Yao Dana. Analysis of the clinical effect of rosuvastatin in elderly chronic heart failure patients and its effect on cardiac function [J]. Contemporary Medicine, 2020,26 (27): 67-69.
Xi Shaojing, Yang Jinlong, Li Fu, Jiang Qingjun, Ma Lina, Dong Lianwei, Zhang Zeying, Ge Lijun. Analysis of the effects of catheter ablation in patients with persistent atrial fibrillation complicated with heart failure [J]. Ningxia Journal of Medicine, 2020,42 (09): 799-802.
Nie Yan. Analysis of the effect of metoprolol and low-dose digoxin in patients with chronic heart failure with fast ventricular rate [J]. Community physicians in China, 2020,36 (10): 86-87.
Ding Wenlong, Fang Cunming. Analysis of the effect of rosuvastatin in elderly patients with chronic heart failure with atrial fibrillation [J]. Contemporary Medicine, 2020,18 (04): 139-140.
Ge Yinghui. Efficacy analysis of atorvastatin and valsartan in chronic atrial fibrillation with heart failure [J]. Huaihai Medicine, 2019,37 (06): 639-641.
Shang Pan Shuan. Analysis of the efficacy of bisoprolol and digoxin in patients with rapid type atrial fibrillation with chronic heart failure [J]. Modern Diagnosis and Treatment, 2019,30 (15): 2577-2578.
Yuan Dongdong. Clinical analysis of 88 cases of warfarin and betgram in coronary heart disease atrial fibrillation with heart failure [J]. Straits Pharmaceutical Sciences, 2019,31 (05): 137-138.
Zhou Yufeng, Wang Meilan. Left atrial appendage occlusion combined with atrial fibrillation ablation in 18 cases of atrial fibrillation combined with severe heart failure [J]. Rural Medicine in China, 2019,26 (07): 65-66.
Zhou Guiling, Zhang Xiaoping, Ma Lin. Clinical study of verapamil combined with deacetylphotriflorin injection in 41 cases with rapid atrial fibrillation combined with acute heart failure [J]. Northern Pharmacy, 2019,16 (03): 94-95.
Zhao Yuqing, Liu Heng, Yang Yanan, Wang Li, Qiao Lina. Efficacy of sacubaretrovalsartan combined with amiodarone in senile heart failure combined with paroxysmal atrial fibrillation [J]. Hebei Pharmaceutical, 2019,41 (03): 404-406 + 410.
Tian Chao, Song Lili, Mi Shaokai, Wang Wenjie, Wang Wei. On the effect of amiodarone and losartan in chronic heart failure with atrial fibrillation [J]. Psychology Monthly, 2019,14 (01): 139-140.
Kuang Chengying. The effect of verapamil combined with deacetylmutriflorin injection in treating rapid atrial fibrillation combined with acute heart failure in coronary heart disease [J]. Chinese Journal of Heart and Heart Rhythm, 2018,6 (02): 105-108.
Mei Yingli. Clinical efficacy of amiodarone with metoprocomol succinate in chronic heart failure with atrial fibrillation with fast ventricular rate [J]. Prescription drugs in China, 2018,16 (06): 55-56.
Bao Zhongwei. Observation of the efficacy of Shensong Yangxin Capsule combined with amiodarone in the treatment of elderly heart failure combined with paroxysmal atrial fibrillation [A] Collection of the 14th International Conference [C]. Department of Medicine and Health of Chinese Academy of Engineering, Chinese Society of Traditional Chinese Medicine, World Federation of Traditional Chinese Medicine Societies, Chinese Rural Health Association, Medical Disease Branch of China Society of Traditional Chinese Medicine, 2018:4.
Huang Sibing. Clinical evaluation of metoprolol combined with low dose digoxin in chronic heart failure with atrial fibrillation with fast ventricular rate [J]. Modern Drug Applications in China, 2018,12 (05): 7-8.
Bao Zhongwei. Efficacy observation of amiodarone and shinsong Yangxin capsule in treating heart failure combined with paroxysmal atrial fibrillation in the elderly [J]. Journal of Anhui University of Traditional Chinese Medicine, 2017,36 (05): 21-25.
Zhang Caijiao. To explore the advantages of combining Chinese and Western medicine in the treatment of chronic heart failure with atrial fibrillation [D]. Yanbian University, 2016.
Su Yanzhou. Clinical effect of amiodarone combined with telmisartan in chronic heart failure combined with paroxysmal atrial fibrillation [J]. Contemporary Medicine, 2016,22 (29): 149-150.
Tang Fangli. Efficacy of cardiac granules combined with carvedilol in chronic heart failure combined with atrial fibrillation [J]. Journal of Clinical Rational Drug Use, 2016,9 (10): 43-44.
Li Dong. Efficacy observation of Qiliqiangxin capsule combined with amiodarone on heart failure combined with paroxysmal atrial fibrillation in elderly patients [J]. Western Traditional Chinese Medicine, 2016,29 (03): 86-88.
Shi Xiaoyan, Deng Li. Clinical efficacy analysis of amiodarone combined with aminylmetoprolol extended-release tablets in patients with atrial fibrillation with heart failure [J]. The Medical Engineering of China, 2014,22 (11): 85 + 88.
Li Xiaoming, Wang Xia. Clinical observation of telmisartan combined with amiodarone in chronic heart failure combined with paroxysmal atrial fibrillation [J]. Northwest Journal of National Defense Medicine, 2013,34 (04): 304-306.
Zhang Qiong, Zhang Yi, Li Hongping. Clinical observation of metoprolol combined with low dose digoxin in chronic heart failure with atrial fibrillation with fast ventricular rate [J]. Sichuan Medical Science, 2013,34 (02): 277-278.
Li Honghao, Wang Yan. Analysis of 20 cases of metoprolol combined with amiodarone treatment in chronic congestive heart failure combined with atrial fibrillation [J]. Chinese Journal of Misdiagnosis, 2011,11 (36): 8997.
Lu Ya e, Wen Ning. Heart granules combined with bisoprolol and digoxin treated 50 patients of chronic heart failure combined with atrial fibrillation [J]. Journal of Shaanxi College of Traditional Chinese Medicine, 2011,34 (05): 22-23.
Liu Shihong, Zhu Jun. Clinical analysis of 66 cases of warfarin and betgram in coronary heart disease atrial fibrillation with heart failure [J]. China Factory and Mining Medicine, 2008, (05): 590.
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