Artificial Sweetener Consumption Increasing Type II Diabetes Risk Revealed by Gut Microbiome
DOI:
https://doi.org/10.54097/hset.v66i.11627Keywords:
Artificial sweeteners, Microbiome, Saccharin, Acesulfame-potassium, Stevia, Type II diabetes.Abstract
Artificial sweeteners, low-caloric sugar substitutes, are widely applied in modern food industry and regularly consumed by people. However, recent studies have shown the increasing disease risk by consuming artificial sweeteners, especially metabolic diseases. In this study, we investigated the effect of three artificial sweeteners, namely, saccharin, acesulfame-potassium, and stevia on Type II diabetes risk by gut microbiome. The study utilized the 16S rRNA gut microbiome data from rat fecal samples to analyze the gut microbiome abundance, composition, and difference between four groups, i.e., acesulfame-potassium, saccharin, stevia, and control group. The most significant gut microbiota changes were identified and used to determine whether the altered bacteria taxa have correlation with glucose intolerance and Type II diabetes. In the end, it is found that the Faecalibacillus genus and Prevotellax genus have significant changes and are closely related with higher risk of Type II diabetes, suggesting acesulfame-potassium and saccharin consumption may increase diabetic risk via altering gut microbiome, while no bacteria taxa change in stevia group is found to be related with glucose intolerance or Type II diabetes. This gut microbiome-based study revealed the key disrupted gut microbiota by artificial sweeteners that were associated with Type II diabetes.
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M. Grembecka, “Natural sweeteners in a human diet,” Rocz Panstw Zakl Hig, vol. 66, no. 3, pp. 195–202, 2015. doi:PMID: 26400114
P. J. Landrigan and K. Straif, “Aspartame and cancer – new evidence for causation,” Environmental Health, vol. 20, no. 1, 2021. doi:10.1186/s12940-021-00725-y
A. Petersmann et al., “Definition, classification and diagnosis of diabetes mellitus,” Experimental and Clinical Endocrinology & Diabetes, vol. 127, no. S 01, 2019. doi:10.1055/a-1018-9078
X. Ma et al., “Excessive intake of sugar: An accomplice of inflammation,” Frontiers in Immunology, vol. 13, 2022. doi:10.3389/fimmu.2022.988481
F. Imamura et al., “Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: Systematic review, meta-analysis, and estimation of population attributable fraction,” BMJ, 2015. doi:10.1136/bmj.h3576
M. Gurung et al., “Role of gut microbiota in type 2 diabetes pathophysiology,” EBioMedicine, vol. 51, p. 102590, 2020. doi:10.1016/j.ebiom.2019.11.051
J. Suez et al., “Artificial sweeteners induce glucose intolerance by altering the gut microbiota,” Nature, vol. 514, no. 7521, pp. 181–186, 2014. doi:10.1038/nature13793
H. M. Hasan, S. Y. Alkass, and D. S. de Oliveira, “Impact of long-term cyclamate and saccharin consumption on biochemical parameters in healthy individuals and type 2 diabetes mellitus patients,” Medicina, vol. 59, no. 4, p. 698, 2023. doi:10.3390/medicina59040698
S. C. S., Y. C. K., and A. B. J., “Comparative evaluation of diabetogenic and mutagenic potential of artificial sweeteners - aspartame, acesulfame-K and sucralose,” Journal of Health and Allied Sciences NU, vol. 02, no. 03, pp. 80–84, 2012. doi:10.1055/s-0040-1709358
R. Sharma, R. Yadav, and E. Manivannan, “Study of effect of Stevia rebaudiana bertoni on oxidative stress in type-2 diabetic rat models,” Biomedicine & Aging Pathology, vol. 2, no. 3, pp. 126–131, 2012. doi:10.1016/j.biomag.2012.07.001
A. Kasti et al., “The effects of stevia consumption on gut bacteria: Friend or foe?,” Microorganisms, vol. 10, no. 4, p. 744, 2022. doi:10.3390/microorganisms10040744
L. O. Nabors, Alternative Sweeteners, 3rd ed. Marcel Dekker, 2001.
E. A. Abou-Arab, A. Abou-Arab, and F. Abu-Salem, “Physico-chemical assessment of natural sweeteners STEVIOSIDES produced from Stevia rebudiana Bertoni Plant,” Journal of Food and Dairy Sciences, vol. 34, no. 12, pp. 11037–11057, 2009. doi:10.21608/jfds.2009.115819
H. Wu et al., “The gut microbiota in prediabetes and diabetes: A population-based cross-sectional study,” Cell Metabolism, vol. 32, no. 3, 2020. doi:10.1016/j.cmet.2020.06.011
X. Zhang et al., “Human gut microbiota changes reveal the progression of glucose intolerance,” PLoS ONE, vol. 8, no. 8, 2013. doi:10.1371/journal.pone.0071108
A. A. Mahmood and S. B. Al-Juboori, “A review: Saccharin Discovery, synthesis, and applications,” Ibn AL- Haitham Journal For Pure and Applied Sciences, vol. 33, no. 2, p. 43, 2020. doi:10.30526/33.2.2442
G.-W. von Rymon Lipinski, “The new intense sweetener acesulfame K,” Food Chemistry, vol. 16, no. 3–4, pp. 259–269, 1985. doi:10.1016/0308-8146(85)90120-7
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