Research Progress: Relationship Between Gut Microbiome and Mental Health
DOI:
https://doi.org/10.54097/47c32q91Keywords:
Gut microbiome, mental health, probiotic treatments, gut-brain axis.Abstract
The relationship between the gut microbiome and mental health has received much attention recently. Recent studies have demonstrated a dual crosstalk relationship within the gut-brain axis (GBA), but some specific mechanisms of their relationship still need to be further explored. Based on recent GBA-related research, this article summarizes and analyzes the intricate connections within GBA and analyzes the potential of probiotic treatment for mental health (especially depression and anxiety). Through analysis, this paper found that a variety of indicators can be used to monitor the effectiveness of treatment processes, including questionnaires and DNA sequencing of stool samples. The clinical application of probiotics can also help relieve symptoms such as anxiety and insomnia, providing patients with a relatively safe treatment option. The conclusions of this article help to provide a reference for the research progress related to GBA and provide new ideas for further exploring the intrinsic mechanism of GBA.
Downloads
References
Bull, M. J., & Plummer, N. T. Part 1: The Human Gut Microbiome in Health and Disease. Integrative Medicine (Encinitas, Calif.), 2014, 13(6), 17–22.
Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. Gut microbiota’s effect on mental health: the gut-brain axis. Clinics and Practice, 2014, 7(4).
The White House. Reducing the economic burden of unmet mental health needs. The White House. https://www.whitehouse.gov/cea/written-materials/2022/05/31/reducing-the-economic-burden-of-unmet-mental-health-needs/. 2022.
Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2), 203–209. 2015.
Yang, Y., Ge, K., & Chinese Nutrition Society. Encyclopedia of Nutrition Science (2nd ed., pp. 403–410). People’s Medical Publishing House. 2019.
Zhu, R., Fang, Y., Li, H., et al. Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college via modulating the gut microbiota and its metabolism. Frontiers in Immunology, 2023, 14.
Duranti, S., Ruiz, L., Lugli, G. A., T et al. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA. Scientific Reports, 2020, 10.
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences, 108(38), 2011, 16050–16055.
Markowiak-Kopeć, P., & Śliżewska, K. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients, 2020, 12(4), 1107.
Paudel, D., Uehara, O., Giri, S., Yoshida, K., et al. Effect of psychological stress on the oral-gut microbiota and the potential oral-gut-brain axis. The Japanese Dental Science Review, 2022, 58, 365–375.
Keskitalo, A., Aatsinki, A.-K., Kortesluoma, S., et al. Gut microbiota diversity but not composition is related to saliva cortisol stress response at the age of 2.5 months. Stress, 2021, 24(5), 551–560.
Stasi, C., Sadalla, S., & Milani, S. The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis. Current Drug Metabolism, 2019, 20(8), 646–655.
Slykerman, R. F., Hood, F., Wickens, K., et al. Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial. EBioMedicine, 2017, 24, 159–165.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Highlights in Science, Engineering and Technology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
