Uric Acid Plays a Key Role in Hypertension and its Long-term Risk

Abstract

Hypertension is a chronic disease now prevalent in modern societies and is a separate heart failure threat. If leave unattended a lengthy amount duration, it may lead to long-term risks such as stroke or heart attack, kidney damage, osteoporosis, and even death. Human metabolism of purines results in uric acid, which may have a significant impact on the onset and subsequent risk of pressure. The connection that exists among uric acid and hypertension was found to be progressively observable in Mendelian randomization studies, but no further strong subsequent studies have been conducted as of 2021 to illustrate the relationship. Meta-analysis studies have shown a potential link between elevated uric acid levels and an increased risk of hypertension, However, there is still a need to investigate the potential benefits of uric acid-lowering medications in reducing the risk of hypertension. Previous studies involving large sample sizes have indicated a positive association between uric acid levels and the likelihood of developing hypertension, but there is some geographic variation in the studies and the conclusions are limited and difficult to generalize. Multiple studies have given possible mechanisms at the mechanistic level for uric acid triggering hypertension or long-term risk, but the evidence-based value is low, giving no strong proof in terms of its relevance and continuity. This paper summarizes the existing evidence in the above points, puts forward its own insights, and looks forward to the future direction of scientific research, with a view to providing some references for future researcht.