Feasible construction of a pH-responsive nanoparticle for smart drug delivery
DOI:
https://doi.org/10.54097/hset.v69i.12220Keywords:
amphiphilic poly (ethylene glycol); acetal; Adriamycin (DOX)Abstract
Endosomal pH-responsive micellar nanoparticles have been prepared by amphiphilic poly (ethylene glycol)-Schiff base-Adriamycin (PEG-Schiff-DOX，PSD) prodrug, and wrapped DOX drugs in the hydrophobic core of the polymeric nanoparticles. Under normal conditions, these nanoparticles showed good stability over a storage period of 7 days but decomposed rapidly under the weakly acidic conditions. These nanoparticles possessed a high drug loading capacity and good cell compatibility that would be promising for the drug carries in the drug delivery system.
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