Principle and Application of Biophotonic Chips
DOI:
https://doi.org/10.54097/2qytj711Keywords:
Biophotonic chips; photolithography; medical diagnosis.Abstract
Contemporarily, biophotonic chips have garnered significant attention from researchers due to their strong immunity to electromagnetic interference, high sensitivity, rapid response rate, and relatively simple structural design. They have found extensive applications in fields such as medical diagnosis, food quality and safety testing, environmental monitoring, and national security. This article provides an overview of the development history, fundamental principles, applications, and fabrication processes of biophotonic chips. The earliest development of biophotonic chips can be traced back to the end of the 20th century. The basic principle involves the interaction of light, utilizing technologies like photonic crystals, surface plasmon resonance, and fluorescence spectroscopy to achieve the detection and analysis of biological molecules. The article briefly describes the fabrication process of biophotonic chips, which involves intricate techniques such as photolithography and electron beam exposure. Furthermore, it analyzes and discusses their widespread applications in medical diagnosis, drug development, and environmental monitoring, among other fields. Lastly, the study evaluates the key challenges present in biophotonic chips and provides an analysis of their future development prospects.
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References
Aris P. Biochips. Nature Biotechnology, 1998, 16: 981-983.
Mohamed I, Krishnendu C. Digital-Microfluidic Biochips, 2016, 10: 1109.
Arvind Chandrasekaran & Muthukumaran Packirisamy. Integrated microfluidic biophotonic chip for laser induced fluorescence detection. Biomedical Microdevices, 2010, 12(5): 923-933.
Harris, T D, Buzby P R, Babcock H, et al. Single-molecule DNA sequencing of a viral genome. Science, 2008, 320(5872): 106-109.
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg S L, Rinn J L, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 2012, 7(3): 562-78
Pires I, Alves A, Queiroga FL, Silva F, Lopes C. Regression of canine cutaneous histiocytoma: reduced proliferation or increased apoptosis. Anticancer Res. 2013, 33(4): 1397-400.
Lucie A L, Christine M, Brian R B, et al. Organs-on-chips: into the next decade. Nature Reviews Drug Discovery, 2021, 20: 345–361.
Tarhan I I, Wastson G H. Photonic Band Structure of fcc Colloidal Crystals. Physical Review Letters, 1996, 76(2): 315-318.
Hess S T, Huang S, Heikal A A, et al. Biological and chemical applications of fluorescence correlation spectroscopy: a review. Biochemistry, 2002, 41(3): 697-705.
Tsigaridas G, Polyzos D, Ioannou A, et al. Theoretical and experimental study of refractive index sensors based on etched fiber Bragg gratings. Sensors and Actuators A: Physical, 2014, 209: 9-15.
Fan X, Shopou I M W S I, Zhu H. Sensitive optical biosensors for unlabeled targets: A review. Analytica chimica acta, 2008, 1(2): 620.
Yan H, Zou Y, Chakaravarty S, et al. Silicon on-chip bandpass filters for the multiplexing of high sensitivity photonic crystal microcavity biosensors. Applied Physics Letters, 2015, 106(12): 229-34.
Kwon M S, Steier W H. Microring-resonator-based sensor measuring both the concentration and temperature of a solution. Optics Express, 2008, 16(13): 9372-7.
Greve J, Lambeck P V, Wink T, et al. Fast, Ultrasensitive Virus Detection Using a Young Interferometer Sensor. Nano Letters, 2007, 7(2): 394-397.
Wang J. Fabrication of polydimethylsiloxane nanofluidic chips under AFM tip-based nanomilling process. Nanoscale research letters, 2019, 14(1): 136.
Fruncillo S, Su X, Liu H, et al. Lithographic Processes for the Scalable Fabrication of Micro- and Nanostructures for Biochips and Biosensors. ACS Sensors, 2021.
Torino S, Corrado B, Iodice M, et al. PDMS-Based Microfluidic Devices for Cell Culture. Inventions, 2018, 3(3).
Qin M, Li Y, Su Y, et al. A Rainbow Structural-Color Chip for Multisaccharide Recognition. Angewandte Chemie, 2016, 55(24).
Fahima A, Shazwani B, Nam-Trung N, et al. Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices. Biosensors, 2020, 10(11): 182.
Leosson K, Agnarsson B. Integrated Biophotonics with CYTOP. Micromachines, 2012, 3(1): 114-125.
Soref R. The Past, Present, and Future of Silicon Photonics. IEEE Journal of Selected Topics in Quantum Electronics, 2006, 12: 1678-1687.
Idrisov E G, Levkivskyi I P, Sukhorukov E V. Dephasing in a Mach-Zehnder Interferometer by an Ohmic Contact. Physical Review Letters, 2018, 121: 026802.
Xu X B, Shi L, Guo G C, Dong C H, Zou C L. Möbius” microring resonator. Applied Physics Letters, 2019, 114: 101106.
Grist S M. Silicon photonic micro-disk resonators for label-free biosensing. Opt Express, 2013, 21: 7994-8006.
Prabhathan P, Murukeshan V M, Jing Z, Ramana P V. Compact SOI nanowire refractive index sensor using phase shifted Bragg grating. Opt Express, 2009, 17: 15330-15341.
Mandal S, Serey X, Erickson D. Nanomanipulation Using Silicon Photonic Crystal Resonators. Nano Letters, 2010, 10: 99-104.
Luan E, Shoman H, Ratner D M, Cheung K C, Chrostowski L. Silicon Photonic Biosensors Using Label-Free Detection, 2018.
Qin K, Hu S, Retterer S T, Kravchenko I I, Weiss S M. Slow light Mach–Zehnder interferometer as label-free biosensor with scalable sensitivity. Opt Lett, 2016, 41: 753-756.
Song B, Zhang H, Liu B, Lin W, Wu J. Label-free in-situ real-time DNA hybridization kinetics detection employing microfiber-assisted Mach-Zehnder interferometer. Biosensors and Bioelectronics, 2016, 81: 151-158.
Tan Y, Dai D. Silicon microring resonators. Journal of Optics, 2018, 20: 054004.
Ali L, Mohammed M U, Khan M, Yousuf A H B, Chowdhury M H. High-Quality Optical Ring Resonator-Based Biosensor for Cancer Detection. IEEE Sensors Journal, 2020, 20: 1867-1875.
Sun C, et al. Scalable On-Chip Microdisk Resonator Spectrometer. Laser & Photonics Reviews, 2023, 17: 2200792.
Chen S, Zhang C, Wang J, et al. A fiber Bragg grating sensor based on cladding mode resonance for label-free biosensing. Biosensors, 2023, 13(1): 97.
Abderrahmane A, Senouci K, Hachemi B, Ko P J. 2D Gallium Sulfide-Based 1D Photonic Crystal Biosensor for Glucose Concentration Detection, 2023.
Li Q, Zhou S, Zhang T, Zheng B, Tang H. Bioinspired sensor chip for detection of miRNA-21 based on photonic crystals assisted cyclic enzymatic amplification method. Biosensors and Bioelectronics, 2020 150: 111866.
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