A brief analysis of the mechanism of treatment of depression based on the 5-HT hypothesis
DOI:
https://doi.org/10.54097/hset.v14i.1851Keywords:
5-ht, depression, hypothesis.Abstract
Depression is the most common form of depressive disorder and is characterised by significant and persistent depression, usually with a prolonged onset (longer than two weeks) and a tendency for recurrent episodes. In today's rapidly developing society, depression is becoming more prevalent at a younger age and therefore research and development of drugs for depression is urgent, but single-target depression treatments are no longer suitable for today's research due to their high cost and toxic side effects. This paper is therefore based on the 5-hydroxytryptamine receptor hypothesis and analyses the pathogenesis of depression as well as the receptors and their mechanisms of action.
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References
Xiao Yuan. Antidepressant effect of glycyrrhizin and its mechanism [D]. Beijing University of Traditional Chinese Medicine, 2009.
Jakab RL, Goldman-Rakic PS. 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA. 1998;95(2):735-40.
Bombardi C, Di Giovanni G. Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions. Exp Brain Res. 2013;230(4):427-39.
Celada P, Puig MV, Artigas F. Serotonin modulation of cortical neurons and networks. Front Integr Neurosci. 2013; 7:25.
Beyer HS, Matta SG, Sharp BM. Regulation of the messenger ri a bomucleicacid for corticotropin-releasing factor in the paraventri acular nucleus and other brain sites of the rat[J]. Endocrino.198H, 123:2117
Du JK, Jensen JB, Sanchez C, Pehrson AL. Vortioxetine dose-dependently reverses 5-HT, depletion-induced deficits in spatial working and object recognition memory: a potential role for, 5-HT1A receptor agonism and 5-HT3 receptor antagonism[J]. European Neuropsychopharmacology. 2014, 24(1): 160-71.
Riemer C, Borroni E, Levet-Trafit B, Martin JR, Poli S, Porter RH, et al. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidine-1-ylpyridine-4-sulfonyl) phenylamine, a potent and selective 5-HT6 receptor antagonist [J]. Journal of Medicinal Chemistry. 2003,46(7):1273-6.
Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466[J]. Neuropsychopharmacology. 2008, 33(6): 1323-35.
Dawson LA, Nguyen HQ, Li P. The 5-HT6 Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus[J]. Neuropsychopharmacology Official Publication of the American College of Neuropsychopharmacology. 2001,25(5):662-8.
Chen S. F. Study on the pro-cognitive 5-HT_6 receptor mechanism of the new antidepressant drug oxypiperidone hydrochloride (YL-0919) [D]. Academy of Military Sciences,2018.
Ramírez MJ. 5-HT6 receptors and Alzheimer's disease[J]. Alzheimers Research & Therapy. 2013,5(2):15.
Codony X, Vela JM, Ramírez MJ. 5-HT (6) receptor and cognition[J]. Current Opinion in Pharmacology. 2011,11(1):94-100.
The UniProt Consortium UniProt: the universal protein knowledgebase in 2021 Nucleic Acids Res. 49:D1 (2021)
B.T. Sherman, M. Hao, J. Qiu, X. Jiao, M.W. Baseler, H.C. Lane, T. Imamichi and W. Chang. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Research. 23 March 2022. doi:10.1093/nar/gkac194. [PubMed]
Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nature Protoc. 2009;4 (1):44-57. [PubMed]
Li YL, Dong QL, Zhang LAN. Research progress of selective pentraxin reuptake inhibitors in the treatment of depression in adolescents[J]. Journal of Practical Clinical Medicine,2022,26(11):138-142+148.
Zhen Haiyan. Analysis of the efficacy of duloxetine hydrochloride in the treatment of menopausal depression[J]. Contemporary Medicine,2022,28(09):112-114.
Fu H Y, Wang X H, Yin S M. The role of 5-hydroxytryptamine 2C receptors in the molecular mechanism of depression[J]. Advances in Physiological Sciences, 2014,45(03):221-224.
Bo Qiang, Xue L. Progress in the study of 5-HT_(2C) receptors and depression[J]. Journal of Medical Research,2012,41(06):5-7.
Wang Yewei, Zhang Chen. Research progress of 5-hydroxytryptamine 2C receptor as a therapeutic target for schizophrenia[J]. Journal of Shanghai Jiaotong University (Medical Edition),2018,38(07):801-804.
Chen Yu. Effects of antidepressants fluoxetine and paroxetine on 5-HTergic neurotransmission system in zebrafish brain tissue[D]. Zhejiang Ocean University,2019. doi: 10.27747/d.cnki.gzjhy.2019.000287.
Heinrichs SC, Tache Y. Therapeutic potential of CRF receptor ant agonists:a gut-brain perspective. Expert Opin Investing Drugs,2001,10:647-659 .
Yamada M, Kawahara Y, Kaneko F, et al. Upregulation of the 5-hydroxytryptamine system in the dorsal raphe nucleus-prefrontal cortex by long-term treatment with escitalopram in low 5-hydroxytryptaminergic Wistar-Kyoto rats[J]. Neuropharmacology, 2013, 72: 169-178.
Su Hui, Shi Shenxun. The regulatory role of 5-HT_(1A) receptors on depressive and anxious behavior and its mechanism[J]. Journal of Shanghai Jiaotong University (Medical Edition),2015,35(09):1403-1406.
Lian B. The role of 5-hydroxytryptamine receptors in autism-like rats and its mechanism[D]. Southwest University, 2020. DOI: 10.27684/d.cnki.gxndx.2020.000038.
Chen Xinyi, Li Yongfeng, Xu Chenxi, Qiao Haifa. Research progress on the effect mechanism of acupuncture intervention in depression in the central 5-hydroxytryptamine system[J]. Chinese Journal of Traditional Chinese Medicine, 2022, 40(07): 150-154. DOI: 10.13193/j.issn.1673-7717.2022.07.037.
Jesse W. Richardson-Jones, Caryne P. Craige, Bruno P. Guiard, et al. 5-HT 1A Autoreceptor Levels Determine Vulnerability to Stress and Response to Antidepressants[J]. NeuronVolume 65, Issue 1, 2009. PP 40-52.
Su Hui,Shi Shenxun.The regulatory role of 5-HT_(1A) receptors on depressive and anxious behavior and its mechanism[J]. Journal of Shanghai Jiaotong University (Medical Edition),2015,35(09):1403-1406.
Cui Hongmei, Gao Hailong, Li Desheng, Sun Jieshu, Ye Ying, Chen Wenlan. Evaluation of the efficacy of combining risperidone and low-dose lithium carbonate in the treatment of chronic schizophrenia in old age[J]. China Practical Medicine,2021,16(01): 160-162. DOI: 10.14163/j.cnki.11-5547/r.2021.01.068.
Yasuhiro Inayamo, Hiroshi Yoneda, Toshiaki Sakai, et al. Positive asso-ciation between a DNA sequence variant in the serotonin 2A receptorgene and schizophrenia [J]. Am J Med Gen (neuropsychiatric genet-ice), 1996, 67:103.
Lu Zheng, Cai Jun, Jiang Sanduo, Wang Dongxiang, Li Xia, Yao Peifen, Xiong Xiangyu. Association analysis of 5-hydroxytryptamine 2A2 and C receptor gene polymorphisms with refractory depression[J]. Journal of Clinical Psychiatry,2005(04):193-195.
Zhao Houfeng, Hu Cunkun, Zhu Xianghua, Geng Deqin. Association of 5-hydroxytryptamine 2C receptor gene polymorphism with depression[J]. Journal of Clinical Psychiatry,2008,18(06):373-375.
LI Fang, WANG Haiping, DI Jianying, HEUNG Qiumei, WANG Qian, YANG Gang, WEI Sheng. Identification of chemical composition of Shu Yu capsule in rat brain and its effect on 5-HT_3R channel function[J]. Journal of Traditional Chinese Medicine, 2021, 27(11): 35-40. DOI: 10.13862/j.cnki.cn43-1446/r.2021.11.010.
Claudia S. The roles of phospholipase C activation and alternative A-DAR1 andADAR2 pre-mRNA splicing in modulating serotonin
Wei H. The role of peripheral 5-hydroxytryptamine 2A receptors in carrageenan-induced pain sensitization and inflammation[D]. Fujian Normal University, 2006.
Jie Yanpeng. Study on the antidepressant mechanism of Chai Hu plus Long Bone Oyster Soup based on 5-HT2AR and CaMK II α expression changes[D]. Heilongjiang Academy of Chinese Medicine, 2020. DOI: 10.27126/d.cnki.ghlzy.2020.000042.
Chen S. F. Study on the pro-cognitive 5-HT_6 receptor mechanism of the new antidepressant drug oxypiperidone hydrochloride (YL-0919) [D]. Academy of Military Sciences, 2018.
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