Microfluidic Technology’s Role in Advancing Cancer Research and Therapy
DOI:
https://doi.org/10.54097/bp37dh19Keywords:
Microfluidic technology, Cancer diagnostics, Personalized therapy Introduction.Abstract
Microfluidic technology, increasingly recognized for its broad applications across various fields, plays a pivotal role in advancing cancer research and treatment. This technology, with its ability to manipulate fluids at the microscale, offers novel approaches to cancer diagnostics and therapy, highlighting its importance in the medical and scientific communities. This review paper discusses three critical aspects: the principles and mechanisms of microfluidic devices in cancer research, the design and fabrication techniques of microfluidic chips, and their applications in cancer detection and treatment. By exploring these facets, the paper aims to show the advancements microfluidic technology brings to oncology, particularly in enhancing early detection, enabling high-throughput screening, and facilitating personalized therapy. The research presented in this review paper holds significant value for future studies on enhancing the accuracy of cancer diagnoses and the personalization of treatment, demonstrating the potential of microfluidic technology to advance cancer care, especially in terms of precision, personalization, and accessibility.
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References
Cancer Tomorrow | IARC, “Estimated numbers from 2022 to 2050, Males and Females, age [0-85+]”, 2022.
U. Veronesi and V. Stafyla, “Grand challenges in surgical oncology,” Front. Oncol., vol. 2, p. 127, October 2012.
R. Wickham, “Chemotherapy-Induced Peripheral Neuropathy: A Review and Implications for Oncology Nursing Practice,” Clin. J. Oncol. Nurs., vol. 11, pp. 361 - 76, July 2007.
R. Baskar, K. A. Lee, R. Yeo, and K. W. Yeoh, “Cancer and radiation therapy: current advances and future directions,” Int. J. Med. Sci., vol. 9, pp. 193 - 9, 2012, doi: 10.7150/ijms.3635.
K. R. Yabroff, J. Lund, D. Kepka, and A. Mariotto, “Economic burden of cancer in the United States: estimates, projections, and future research,” Cancer Epidemiol. Biomarkers Prev., vol. 20, pp. 2006 - 14, October 2011.
A. Afghahi and G. W. Sledge, Jr., “Targeted Therapy for Cancer in the Genomic Era,” Cancer J, vol. 21, pp. Aug 2015.
A. Manz, N. Graber, and H. M. Widmer, “Miniaturized total chemical analysis systems: A novel concept for chemical sensing,” Sens. Actuators B Chem., vol. 1, pp. 244 - 248, January 1990.
G. M. Whitesides, “The origins and the future of microfluidics,” Nature, vol. 442, no. 7101, pp. 368-373, 2006/07/01 2006, doi: 10.1038/nature05058.
H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering Flows in Small Devices: Microfluidics Toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech., vol. 36, pp. 381 - 411, January 2004.
T. M. Squires and S. R. Quake, “Microfluidics: Fluid physics at the nanoliter scale,” Rev. Mod. Phys., vol. 77, pp. 977 - 1026, October 2005.
S. L. Anna, N. Bontoux, and H. A. Stone, “Formation of dispersions using “flow focusing” in microchannels,” Appl. Phys. Lett., vol. 82, pp. 364-366, January 2003.
Y. Xia and G. M. Whitesides, “Soft Lithography,” Angew. Chem. Int. Ed., vol. 37, pp. 550-575, March 1998.
M. M. Stanton, J. Samitier, and S. Sánchez, “Bioprinting of 3D hydrogels,” Lab Chip, vol. 15, no. 15, pp. 3111 - 3115, June 2015.
J. Wang, C. J. Bettinger, R. S. Langer, and J. T. Borenstein, “Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly (ester amide) elastomers,” Organogenesis, vol. 6, pp. 212 - 6, Oct 2010.
Y. Wu, P. Xue, K. M. Hui, and Y. Kang, “A paper-based microfluidic electrochemical immunodevice integrated with amplification-by-polymerization for the ultrasensitive multiplexed detection of cancer biomarkers,” Biosensors and Bioelectronics, vol. 52, pp. 180-187, Feburary 2014.
Q. Jiang et al., “Bladder cancer hunting: A microfluidic paper-based analytical device,” Electrophoresis, vol. 4, pp. 1509 - 1516, June 2020.
S. Wan et al., “New Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma,” Sci. Rep., vol. 9, p. 18575, December 2019.
M. S. Bakhshi, M. Rizwan, G. J. Khan, H. Duan, and K. Zhai, “Design of a novel integrated microfluidic chip for continuous separation of circulating tumor cells from peripheral blood cells,” Sci. Rep., vol. 12, p. 17016, October 2022.
H. Hashemzadeh, S. Shojaeilangari, A. Allahverdi, M. Rothbauer, P. Ertl, and H. Naderi-Manesh, “A combined microfluidic deep learning approach for lung cancer cell high throughput screening toward automatic cancer screening applications,” Sci. Rep., vol. 11, p. 9804, May 2021.
A. Lashkaripour et al., “Machine learning enables design automation of microfluidic flow-focusing droplet generation,” Nat. Commun., vol. 12, p. 25, January 2021.
B. Schuster et al., “Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids,” Nat. Commun., vol. 11, p. 5271, October 2020.
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