Wearable Biosensors for Non-invasive Sweat Analysis
DOI:
https://doi.org/10.54097/hfg0v336Keywords:
Wearable Biosensor, Microfluidics, Biosensing Assay, Sweat Analysis.Abstract
Wearable biosensors, especially sweat sensors have drawn significant attention in recent years. Sweat is of importance for its wealth of biomarkers about physiological states. It is therefore utilized for health monitoring, exercise monitoring and so on. Physiological states of individuals can be analyzed through non-invasive wearable sweat biosensors. This paper introduces progress made in sweat sensing technology, including soft materials and microfluidic networks that achieved sweat collection without evaporation. Recent research improved sweat capture of rest individuals and led to robust biosensing assays involving the integration of biosensing arrays and flexible substrates. Novel non-invasive wearable sweat biosensors for the analysis of glucose, alcohol, lactate, and urea were also proposed recently, as well as a sweat sensor capable of analyzing these biomarkers simultaneously. These biosensors all had outstanding sensitivity, selectivity, and stability. While existing wearable sweat sensors have multiple challenges, the future of non-invasive sweat sensing is still promising.
Downloads
References
J. Kim, A.S. Campbell, B.E.F. de Ávila, and J. Wang, “Wearable biosensors for healthcare monitoring,” Nat. Biotechnol., vol. 37, pp. 389–406, Feb 2019.
Y. Yang, and W. Gao, “Wearable and flexible electronics for continuous molecular monitoring,” Chem. Soc. Rev., vol. 48, pp. 1465–1491, April 2018.
A. Jeyaram, and S.M. Jay, “Preservation and storage stability of extracellular vesicles for therapeutic applications,” AAPS J., vol. 20, pp. 1–7, November 2017.
S. Jo, D. Sung, S. Kim, and J. Koo, “A review of wearable biosensors for sweat analysis,” Biomed. Eng. Lett., vol. 11, pp. 117–129, May 2021.
S.M. Shirreffs, and R.J. Maughan, “Whole body sweat collection in humans: An improved method with preliminary data on electrolyte content,” J. Appl. Physiol., vol. 82, pp. 336–341, January 1997.
N.A.S. Taylor, and C.A. Machado-Moreira, “Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans,” Extreme Physiol. Med., vol. 2, pp. 1–30, February 2013.
W. Gao, S. Emaminejad, H.Y.Y. Nyein, et al, “Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis,” Nature, vol. 529, pp. 509–514, January 2016.
Y.S. Guan, Z. Zhang, Y. Tang, J. Yin, S. Ren, “Kirigami‐inspired nanoconfined polymer conducting nanosheets with 2000% stretchability,” Adv. Mater., vol. 30, pp. 1706390, March 2018.
K. Zhou, C. Zhang, Z. Xiong, H.Y. Chen, et al, “Template-Directed Growth of Hierarchical MOF Hybrid Arrays for Tactile Sensor,” Adv. Funct. Mater., vol. 30, pp. 2001296, July 2020.
L. Cheng, W. Qian, L. Wei, et al, “A highly sensitive piezoresistive sensor with interlocked graphene microarrays for meticulous monitoring of human motions,” J. Mater. Chem. C, vol. 8, pp. 11525–11531, July 2020.
J. Choi, D. Kang, S. Han, S.B. Kim, J.A. Rogers, “Thin, soft, skin‐mounted microfluidic networks with capillary bursting valves for chrono‐sampling of sweat,” Adv. Healthcare Mater., vol. 6, pp. 1601355, January 2017.
Z. Sonner, E. Wilder, T. Gaillard, et al, “Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest,” Lab Chip, vol. 17, pp. 2550–2560, July 2017.
P. Simmers, S.K. Li, G. Kasting, J. Heikenfeld, “Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol,” J. Dermatol. Sci., vol. 89, pp. 40–51, January 2018.
M. Parrilla, R. Cánovas, I. Jeerapan, et al, “A textile‐based stretchable multi‐ion potentiometric sensor,” Adv. Healthcare Mater., vol. 5, pp. 996–1001, March 2016.
Z. Hao, Z. Wang, Y. Li, et al, “Measurement of cytokine biomarkers using an aptamer-based affinity graphene nanosensor on a flexible substrate toward wearable applications,” Nanoscale, vol. 10, pp. 21681–21688, October 2018.
J. Kim, I. Jeerapan, S. Imani, et al, “Noninvasive alcohol monitoring using a wearable tattoo-based iontophoretic-biosensing system,” ACS Sens., vol. 1, pp. 1011–1019, July 2016.
C. Zhao, X. Li, Q. Wu, X. Liu, “A thread-based wearable sweat nanobiosensor,” Biosens. Bioelectron., vol. 188, pp. 113270, September 2021.
R. Wang, Q. Zhai, T. An, et al, “Stretchable gold fiber-based wearable textile electrochemical biosensor for lactate monitoring in sweat,” Talanta, vol. 222, pp. 121484, January 2021.
Y.C. Lin, M. Rinawati, L.Y. Chang, et al, “A non-invasive wearable sweat biosensor with a flexible N-GQDs/PANI nanocomposite layer for glucose monitoring,” Sens. Actuators, B, vol. 383, pp. 133617, May 2023.
M. Yu, Y.T. Li, Y. Hu, et al, “Gold nanostructure-programmed flexible electrochemical biosensor for detection of glucose and lactate in sweat,” J. Electroanal. Chem., vol. 882, pp. 115029, February 2021.
G. Ibáñez-Redín, G.R. Cagnani, N.O. Gomes, et al, “Wearable potentiometric biosensor for analysis of urea in sweat,” Biosens. Bioelectron., vol. 223, pp. 114994, March 2023.
M.A. Yokus, T. Songkakul, V.A. Pozdin, et al, “Wearable multiplexed biosensor system toward continuous monitoring of metabolites,” Biosens. Bioelectron., vol. 153, pp. 112038, April 2020.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Highlights in Science, Engineering and Technology

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.







