Development of Silk Fibroin Dressings and Advances in Their Application in Wound Healing
DOI:
https://doi.org/10.54097/xgxyfg52Keywords:
Silk Fibroin; Biological activity; Wound dressing; Wound repair; Skin.Abstract
Wound healing is a complex process involving hemostasis, inflammation, proliferation, and remodeling phases. Medical wound dressings are commonly employed to promote wound healing, alleviate patient discomfort, and prevent further tissue inflammation or expedite wound closure. Among various wound dressings, silk fibroin dressings have garnered widespread attention due to their outstanding anti-inflammatory and hemostatic properties, as well as excellent biocompatibility. Therefore, this paper introduces the biological characteristics of silk fibroin, elucidates the current research status of silk fibroin-based wound dressings in various forms such as nanofibers, hydrogels, films, foams, and ointments, and discusses the challenges and future research directions in the field of silk fibroin-based dressings for wound repair, providing insights for further development and application of silk fibroin dressings.
Downloads
References
MENON G K. New insights into skin structure: scratching the surface [J]. Adv Drug Deliver Rev, 2002, 54(S3-S17.
WANG R, LI J Z, CHEN W, et al. A Biomimetic Mussel-Inspired ε-Poly-L-lysine Hydrogel with Robust Tissue-Anchor and Anti-Infection Capacity [J]. Adv Funct Mater, 2017, 27(8):
DAHLKE H, DOCIU N, THURAU K. Thrombogenicity Of Different Suture Materials as Revealed by Scanning Electron-Microscopy [J]. J Biomed Mater Res, 1980, 14(3): 251-68.
CHOUHAN D, MANDAL B B. Silk biomaterials in wound healing and skin regeneration therapeutics: From bench to bedside [J]. Acta Biomater, 2020, 103(24-51.
KUNDU B, RAJKHOWA R, KUNDU S C, et al. Silk fibroin biomaterials for tissue regenerations [J]. Adv Drug Deliver Rev, 2013, 65(4): 457-70.
THURBER A E, OMENETTO F G, KAPLAN D L. bioresponses to silk proteins [J]. Biomaterials, 2015, 71(145-57.
PATIL P P, REAGAN M R, BOHARA R A. Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings [J]. Int J Biol Macromol, 2020, 164(4613-27.
WEI W, LIU J, PENG Z B, et al. Gellable silk fibroin-polyethylene sponge for hemostasis [J]. Artif Cell Nanomed B, 2020, 48(1): 28-36.
KUNDU B, SCHLIMP C J, NURNBERGER S, et al. Thromboelastometric and platelet responses to silk biomaterials [J]. Scientific reports, 2014, 4(4945.
WANG Y Q, YAO D Y, LI L H, et al. Effect of Electrospun Silk Fibroin-Silk Sericin Films on Macrophage Polarization and Vascularization [J]. ACS Biomater Sci Eng, 2020, 6(6): 3502-12.
SANTIN M, MOTTA A, FREDDI G, et al. evaluation of the inflammatory potential of the silk fibroin [J]. J Biomed Mater Res, 1999, 46(3): 382-9.
RNJAK-KOVACINA J, WRAY L S, GOLINSKI J M, et al. Arrayed Hollow Channels in Silk-Based Scaffolds Provide Functional Outcomes for Engineering Critically Sized Tissue Constructs [J]. Adv Funct Mater, 2014, 24(15): 2188-96.
ETIENNE O, SCHNEIDER A, KLUGE J A, et al. Soft Tissue Augmentation Using Silk Gels: An In Vitro and In Vivo Study [J]. J Periodontol, 2009, 80(11): 1852-8.
CHOUHAN D, LOHE T U, SAMUDRALA P K, et al. In Situ Forming Injectable Silk Fibroin Hydrogel Promotes Skin Regeneration in Full Thickness Burn Wounds [J]. Adv Healthc Mater, 2018, 7(24):
STOPPATO M, STEVENS H Y, CARLETTI E, et al. Effects of silk fibroin fiber incorporation on mechanical properties, endothelial cell colonization and vascularization of PDLLA scaffolds [J]. Biomaterials, 2013, 34(19): 4573-81.
PARK Y R, SULTAN M T, PARK H J, et al. NF-κB signaling is key in the wound healing processes of silk fibroin (vol 67, pg 183, 2018) [J]. Acta Biomater, 2018, 72(461-.
CHOUHAN D, JANANI G, CHAKRABORTY B, et al. Functionalized PVA-silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling [J]. J Tissue Eng Regen M, 2018, 12(3): E1559-E70.
ABDEL-NABY W, COLE B, LIU A H, et al. Treatment with solubilized Silk-Derived Protein (SDP) enhances rabbit corneal epithelial wound healing [J]. Plos One, 2017, 12(11):
BUCKNALL T E, TEARE L, ELLIS H. The Choice of a Suture to Close Abdominal Incisions [J]. Eur Surg Res, 1983, 15(2): 59-66.
WANG Y, RUDYM D D, WALSH A, et al. degradation of three-dimensional silk fibroin scaffolds [J]. Biomaterials, 2008, 29(24-25): 3415-28.
ZHOU Z Y, CUI J, WU S L, et al. Silk fibroin-based biomaterials for cartilage/osteochondral repair [J]. Theranostics, 2022, 12(11): 5103-24.
HUANG G P, YANG D F, SUN C F, et al. A quicker degradation rate is yielded by a novel kind of transgenic silk fibroin consisting of shortened silk fibroin heavy chains fused with matrix metalloproteinase cleavage sites [J]. J Mater Sci-Mater M, 2014, 25(8): 1833-42.
WU J D, DING Y J, WANG J Q, et al. Facile fabrication of nanofiber- and micro/nanosphere-coordinated PVDF membrane with ultrahigh permeability of viscous water-in-oil emulsions [J]. J Mater Chem A, 2018, 6(16): 7014-20.
WANG Z K, SONG X L, CUI Y H, et al. Silk fibroin H-fibroin/poly (ε-caprolactone) core-shell nanofibers with enhanced mechanical property and long-term drug release [J]. J Colloid Interf Sci, 2021, 593(142-51.
LEYVA-L PEZ N, GUTI RREZ-GRIJALVA E P, VAZQUEZ-OLIVO G, et al. Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties [J]. Molecules, 2017, 22(6):
KHAN A U R, KAI H, ZHAO J Z, et al. PLCL/Silk fibroin based antibacterial nano wound dressing encapsulating oregano essential oil: Fabrication, characterization and biological evaluation [J]. Colloid Surface B, 2020, 196(
SELVARAJ S, FATHIMA N N. Fenugreek Incorporated Silk Fibroin Nanofibers-A Potential Antioxidant Scaffold for Enhanced Wound Healing [J]. Acs Appl Mater Inter, 2017, 9(7): 5916-26.
BASAL G, TETIK G D, KURKCU G, et al. Olive Leaf Extract Loaded Silk Fibroin/Hyaluronic Acid Nanofiber Webs for Wound Dressing Applications [J]. Dig J Nanomater Bios, 2016, 11(4): 1113-23.
XU X Q, WANG X S, QIN C X, et al. Silk fibroin/poly-(L-lactide-co-caprolactone) nanofiber scaffolds loaded with Huangbai Liniment to accelerate diabetic wound healing [J]. Colloid Surface B, 2021, 199(
HEIDARI M K, POURMADADI M, YAZDIAN F, et al. Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations [J]. Biotechnol Progr, 2023, 39(3):
PENG Y, MA Y, BAO Y, et al. Electrospun PLGA/SF/artemisinin composite nanofibrous membranes for wound dressing [J]. Int J Biol Macromol, 2021, 183(68-78.
KHAN R S, RATHER A H, WANI T U, et al. A comparative review on silk fibroin nanofibers encasing the silver nanoparticles as antimicrobial agents for wound healing applications [J]. Mater Today Commun, 2022, 32(
ZHENG H Y, ZUO B Q. Functional silk fibroin hydrogels: preparation, properties and applications [J]. J Mater Chem B, 2021, 9(5): 1238-58.
LYU Y, LIU Y, HE H, et al. Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering [J]. Gels, 2023, 9(5):
ZAHOOR S, TAHIR H M, ALI S, et al. Diabetic wound healing potential of silk sericin protein based hydrogels enriched with plant extracts [J]. Int J Biol Macromol, 2023, 242(
YU R, YANG Y T, HE J H, et al. Novel supramolecular self-healing silk fibroin-based hydrogel via host-guest interaction as wound dressing to enhance wound healing [J]. Chem Eng J, 2021, 417(
YIN C J, HAN X S, LU Q Y, et al. Rhein incorporated silk fibroin hydrogels with antibacterial and anti-inflammatory efficacy to promote healing of bacteria-infected burn wounds [J]. Int J Biol Macromol, 2022, 201(14-9.
JU H W, LEE O J, MOON B M, et al. Silk fibroin based hydrogel for regeneration of burn induced wounds [J]. Tissue Eng Regen Med, 2014, 11(3): 203-10.
THANGAVEL P, RAMACHANDRAN B, KANNAN R, et al. Biomimetic hydrogel loaded with silk and L-proline for tissue engineering and wound healing applications [J]. J Biomed Mater Res B, 2017, 105(6): 1401-8.
ZAHRA D, SHOKAT Z, AHMAD A, et al. exploring the recent developments of alginate silk fibroin material for hydrogel wound dressing: A review [J]. Int J Biol Macromol, 2023, 248(
CHEN Z Y, ZHANG X N, LIANG J W, et al. Preparation of Silk Fibroin/Carboxymethyl Chitosan Hydrogel under Low Voltage as a Wound Dressing [J]. Int J Mol Sci, 2021, 22(14):
MAZUREK L, SZUDZIK M, RYBKA M, et al. Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing [J]. Biomolecules, 2022, 12(12):
BAI M Y, HSUEH Y W. Evaluation of silk fibroin protein/poly (vinyl alcohol) transparent membranes as prospective patch for acne care [J]. J Bioact Compat Pol, 2015, 30(5): 490-508.
ROH D H, KANG S Y, KIM J Y, et al. Wound healing effect of silk fibroin/alginate-blended sponge in full thickness skin defect of rat [J]. J Mater Sci-Mater M, 2006, 17(6): 547-52.
BAI M Y, CHEN M C, YU W C, et al. Foam dressing incorporating herbal extract: An all-natural dressing for potential use in wound healing [J]. J Bioact Compat Pol, 2017, 32(3): 293-308.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Highlights in Science, Engineering and Technology

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.







