Progress in the Application of Intestinal Flora in the Treatment of Depression
DOI:
https://doi.org/10.54097/vzswmh74Keywords:
GBA, depression, intestinal flora.Abstract
Depression is a common mental disorder in modern society, which seriously threatens the mental health of patients. Many patients commit suicide because of it, which has a huge negative impact on families and society. There are many factors for depression. At present, research suggests that the composition of the gut microbiota is inextricably linked to the risk of depression. The brain and gut communicate with each other through the gastrointestinal tract and the nervous system, which enables the brain to adjust the local movement of the gut, and the function of brain is in turn influenced by the microbes in the gut. However, more experiments are needed to verify this conclusion. This paper mainly analyzes the mechanism of action between the brain and the gut between the gut and the brain, explores the connection between the two, and further analyzes the impact of the metabolites of the intestinal flora and neurotransmitters on the brain, so as to find the treatment of depression: Fecal microbiota transplantation and the intake of probiotics, as two new methods for the treatment of depression, can provide more accurate treatment for patients and solve the problem from the root cause. This article can provide some practical theoretical basis for related research. It is hoped that more researchers will be able to conduct more research in the future and make up for the vacancy of the experiment.
Downloads
References
Yang Y, Cao D, Lyu T, et al. Meta-analysis of a mindfulness yoga exercise intervention on depression–based on intervention studies in China. Frontiers in Psychology, 2023, 14: 1283172.
Shoib S, Chandradasa M, Saeed F, et al. Suicide, stigma and COVID-19: a call for action from low and middle-income countries. Frontiers in psychiatry, 2022, 13: 894524. World Health Organization (WHO) statistics.
Sun Jin, Xu Rui, Zhang Yunfeng, et al. Research progress of microbial-gut-brain axis. Comprehensive clinical practice in China, 2021, 37 (5): 466-470.3.
Radford-Smith DE, Anthony DC. Prebiotic and Probiotic Modulation of the Microbiota-Gut-Brain Axis in Depression. Nutrients. 2023 Apr 13; 15 (8): 1880.
McVey Neufeld KA, Bienenstock J, Bharwani A, et al. Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut-brain signalling. Sci Rep, 2019, 9 (1): 14290.
Chen CM, Wu CC, Huang CL, et al. Lactobacillus plantarum PS128 promotes intestinal motility, mucin production, and serotonin signaling in mice. Probiotics Antimicrob Proteins, 2022, 14 (3): 535-545.
Kambe J, Watcharin S, Makioka-Itaya Y, et al.Heatkilled Enterococcus fecalis (EC-12) supplement alters the expression of neurotransmitter receptor genes in the prefrontal cortex and alleviates anxiety-like behavior in mice.Neurosci Lett, 2020, 720: 134753.
Kiriyama Y, Nochi H. The biosynthesis, signaling, and neurological functions of bile acids [J]. Biomolecules, 2019, 9 (6): 232.
Sun J, Wang F, Hong G, et al. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience Letters, 2016, 618: 159−166.
Skonieczna-Żydecka K, Grochans E, Maciejewska D, et al. Faecal short chain fatty acids profile is changed in Polish depressive women. Nutrients, 2018, 10 (12): 1939.
Gallo R.L., Hooper L.V. Epithelial antimicrobial defenses of the skin and gut. Nat. Rev. Immunol. 2012; 12: 503-516.
Jing YL, Yu Y, Bai F, et al. Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis. Microbiome, 2021, 9 (1): 59.
Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA. Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 2019, 18 (5): 379-401.
Wang XY, Sun GQ, Feng T, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. Cell Research, 2019, 29 (10): 787-803.
Sampson TR, Debelius JW, Thron T, et, al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease. Cell, 2016, 167 (6): 1469-1480.e12.
Devita M., De Salvo R., Ravelli A., et al. Recognizing depression in older adults: practical guidelines and challenges for clinical management. A neuropsychiatrist. Dis. Treat. 2022; 18: 2867-2880.
Sun J. WANG F. HU X. et al. Clostridium butyricum attenuates chronic unpredictable mild stress. induced depressive. like behavior in mice via the gut-brain axis. Journal of Agricultural and Food Chemistry, 2018, 66 (31): 8415-8421.
Liu W H, Chuang H L. Huang Y T, et al. Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PSl28 in germ-free mice. Behavioural Brain Research, 2016, 298: 202—209.
Allen A P, Hutch W, Borre Y E, et al. Bifidobacterium longum 1714 as a translational psychobiotic. modulation of stress. electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry, 2016, 6 (11): e939.
Yun S W’Kim J K, Han M J, et al. Lacticaseibacillus paracasei NK 112 mitigates Escherichia coli-induced depression and cognitive impairment in mice by regulating IL-6 expression and gut microbiota. Beneficial Microbes, 2021, 12 (6): 541-551.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Highlights in Science, Engineering and Technology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
