The Effect of Povidone-Iodine for The Prevention of Pneumonia
DOI:
https://doi.org/10.54097/yq493h29Keywords:
Povidone-iodine; pneumonia; preventive healthcare.Abstract
Background: Pneumonia poses a significant health threat and adversely affects the well-being and recovery of patients, particularly the elderly. With the growing emphasis on preventive healthcare and the rise in population aging, the prevention of pneumonia has become increasingly crucial. Povidone-iodine, a readily available and potent bactericidal disinfectant, has garnered attention for its potential in preventing pneumonia through oral disinfection. Objective: To evaluate the preventive effect of povidone-iodine on pneumonia. Methods: This article systematically searched for published studies in English and Chinese database between 2004 and 2024. This study included studies reporting the clinical application and effect of povidone iodine and the incidence of pneumonia. The raw data from these studies were pooled into the analysis of this article. The statistical analyses used in this study were performed using Stata version 17.0 (Stata Corp LLC, College Station, TX). Results: Fifteen studies were included in the study analysis. Nine studies showed that povidone-iodine reduced the incidence of pneumonia compared with saline, placebo, and oral care . The remaining 4 articles all showed the positive effect of povidone-iodine on the prevention of pneumonia. Two other studies showed that chlorhexidine oral care was more effective than povidone-iodine in preventing pneumonia, but only one study was statistically significant. Conclusion: The use of povidone iodine for gargling, mouth and nose care is a protective factor against pneumonia. It has important implications for pneumonia prevention strategies.
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References
Partridge L, Deelen J, Slagboom PE. Facing up to the global challenges of ageing. Nature. 2018,561(7721):45-56.
Liu YN, Zhang YF, Xu Q, et al. Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study. Lancet Microbe, 2023,4(5):e330-e339.
GBD 2015 LRI Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis, 2017, 17(11):1133-1161.
Cunha BA. Pneumonia in the elderly. Clin Microbiol Infect, 2001, 7(11):581-588.
Emami Zeydi A, Parvizi A, Haddadi S, et al. Effect of Oral Care with Povidone-Iodine in the Prevention of Ventilator-Associated Pneumonia; a Systematic Review and Meta-Analysis. Arch Acad Emerg Med, 2023, 11(1):e31.
Frank S, Capriotti J, Brown SM, Tessema B. Povidone-Iodine Use in Sinonasal and Oral Cavities: A Review of Safety in the COVID-19 Era. Ear Nose Throat J, 2020,99(9):586-593.
WHO coronavirus (COVID-19) dashboard. https://covid19.who. int/. [Accessed 9 August 2021].
Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020,382:1564–7.
Chebib N, Cuvelier C, Malézieux-Picard A, Parent T, Roux X, Fassier T, Müller F, Prendki V. Pneumonia prevention in the elderly patients: the other sides. Aging Clin Exp Res, 2021,33(4):1091-1100.
Sjogren P, Nilsson E, Forsell M et al. A systematic review of the preventive efect of oral hygiene on pneumonia and respiratory tract infection in elderly people in hospitals and nursing homes: efect estimates and methodological quality of randomized controlled trials. J Am Geriatr Soc, 2008, 56:2124–2130.
Kanagalingam J, Feliciano R, Hah JH, Labib H, Le TA, Lin JC. Practical use of povidone-iodine antiseptic in the maintenance of oral health and in the prevention and treatment of common oropharyngeal infections. Int J Clin Pract, 2015, 69(11):1247-1256.
Seguin P, Laviolle B, Dahyot-Fizelier C, et al. Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial. Crit Care Med, 2014, 42(1):1-8.
Chua JV, Dominguez EA, Sison CMC, Berba RP. The efficacy of povidone-iodine oral rinse in preventing ventilator-associated pneumonia: a randomized, double-blind, placebo-controlled (VAPOR) trial:preliminary report. Philipp J Microbiol Infect Dis, 2004, 33(153):e61.
Sato M, Yoshihara A, Miyazaki H. Preliminary study on the effect of oral care on recovery from surgery in elderly patients [published correction appears in J Oral Rehabil, 2007, 34(1):77.
Seguin P, Tanguy M, Laviolle B, Tirel O, Mallédant Y. Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma. Crit Care Med, 2006, 34(5):1514-1519.
Ishikawa A, Yoneyama T, Hirota K, Miyake Y, Miyatake K. Professional oral health care reduces the number of oropharyngeal bacteria. J Dent Res, 2008, 87(6):594-598.
Gupta P, Jethava D. Comparison of the Effectiveness of Oral Care with Chlorhexidine and Povidone iodine on the Incidence of Ventilator Associated Pneumonia in ICU–A prospective randomized controlled study. J Dent Med Sci, 2014,13(11):70-4.
Seguin P, Laviolle B, Dahyot-Fizelier C, et al. Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial. Crit Care Med, 2014, 42(1):1-8.
Seet RCS, Quek AML, Ooi DSQ, et al. Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial. Int J Infect Dis. 2021,106:314-322.
DING Ruixue, ZHAO Huili, PENG Yuanzheng, et al. Application effect of povidone-iodine gargle in oral health management of patients with endotracheal intubation in intensive care unit. Jiangsu Health Care,2023,25(03):178-180.
Effect of povidone-iodine oral pretreatment on oropharyngeal pathogens and lower respiratory tract infection in elderly patients undergoing spinal surgery under general anesthesia. Journal of Local Surgery,2023,32(05):421-424.
Xu Meiqing, Chen Yingping, Xu Jiana.Application of povidone-iodine gargle in oral care of critically ill patients in neurosurgery. Qilu Journal of Nursing,2022,28(06):86-88.
Huang Lipeng, Jiang Xuli. Analysis of the effectiveness of povidone iodine oral and pharyngeal disinfection in preventing ventilator-associated pneumonia. Chinese Journal of Preventive Medicine,2018,19(05):398-400.
Gao Ling, Wang Yanxia, Zhang Lizhen, et al. Povidone-iodine oral care on the prevention of ventilator-associated pneumonia in patients with severe burns. Journal of Advanced Nursing Education,2012,27(08):721-722.
Effect of povidone-iodine in the prevention of ventilator-associated pneumonia. Modern Clinical Medicine,2012,38(01):75-77.
Xu Hualan, Ren Xingzhen. Clinical significance of oral care for critically ill patients. Journal of Chinese and Foreign Medical Research, 2012,10 (03): 108-109.
LI Yanhong,OUYANG Ying,ZHANG Jianyi. Application of povidone-iodine in oral care of patients with oral mechanical ventilation. Nursing Practice and Research,2009,6(12):13-14.
Fuse Y, Ito Y, Yamaguchi M, Tsukada N. Correction to: High Ingestion Rate of Iodine from Povidone-Iodine Mouthwash. Biol Trace Elem Res, 2023,201(6):3131.
Lim NA, Teng O, Ng CYH, et al. Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review. Ann Med, 2022,54(1):1488-1499.
An TH, Ahn BR. Pneumonia due to aspiration of povidine iodine after induction of general anesthesia -A case report-. Korean J Anesthesiol, 2011,61(3):251-256.
Choi WY, Park CW, Son KM, Cheon JS. Aspiration pneumonitis due to povidone-iodine aspiration during a facial bone fracture reduction operation. J Craniofac Surg, 2014,25(2):e172-e174.
Hitosugi T, Tsukamoto M, Yokoyama T. Pneumonia due to aspiration of povidine iodine after preoperative disinfection of the oral cavity. Oral Maxillofac Surg, 2019,23(4):507-511.
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