A Comprehensive Literature Review on The Interplay Between Genetic and Environmental Factors in Mental Illnes
DOI:
https://doi.org/10.54097/tzqc3s86Keywords:
Genetic factors, environmental factors, gene-environment interactions, epigenetics, mental illness.Abstract
This essay examines genetic factors and explores environmental factors while considering gene-environment interactions. Using a specific disorder, commonly perceived as influenced by either genetic factors or environmental factors, it illustrates how genetic predispositions and life experiences intertwine. Lastly, it discusses the role of epigenetics, where environmental factors lead to stable changes in gene expression, ultimately affecting mental health. This discussion supports the view that the relative significance of genetic factors versus environmental factors in causing mental illness depends on the type of disorder under consideration. Furthermore, it underscores the pivotal role of gene-environment interactions in the majority of mental disorders.
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Kendler, K. S. (2005a). “A gene for...”: The nature of gene action in psychiatric disorders. American Journal ofPsychiatry, 162(7), 1243– 1252. Available at: https://doi.org/10.1176/appi.ajp.162.7.1243
Cardoso, A.R. et al. (2019) Essential genetic findings in neurodevelopmental disorders - human genomics, BioMed Central. Available at: https://humgenomics.biomedcentral.com/articles/10.1186/s40246-019- 0216-4
Antonarakis, S.E. et al. (2020) Down syndrome, Nature News. Available at: https://www.nature.com/articles/s41572-019-0143-7
Liogier d’Ardhuy, X. et al. (2015b) Assessment of cognitive scales to examine memory, executive function and language in individuals with Down Syndrome: Implications of a 6-month observational study, Frontiers. Available at: https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00300/full Sebat J;Lakshmi B;Malhotra D;Troge J;Lese-Martin C;Walsh T;Yamrom B;Yoon S;Krasnitz A;Kendall J;Leotta A;Pai D;Zhang R;Lee YH;Hicks J;Spence SJ;Lee AT;Puura K;Lehtim ki T;Ledbetter D;Gregersen PK;Bregman J;Sutcliffe JS;Jobanputra V;Chung W;Warburton D;Kin -n.d. Strong association of de novo copy number mutations with autism, Science (New York, N.Y.). Available at: https://pubmed.ncbi.nlm.nih.gov/ 17363630/
Gan, L. et al. (2018a) Converging pathways in neurodegeneration, from genetics to mechanisms, Nature News. Available at: https://www.nature.com/articles/s41593-018-0237-7
Jones L; Holmans PA;Hamshere ML;Harold D;Moskvina V;Ivanov D;Pocklington A;Abraham R;Hollingworth P;Sims R;Gerrish A;Pahwa JS;Jones N;Stretton A;Morgan AR;Lovestone S;Powell J;Proitsi P;Lupton MK;Brayne C;Rubinsztein DC;Gill M;Lawlor B;Lynch A;Morgan K;Bro (no date) Genetic evidence implicates the immune system and [1]
cholesterol metabolism in the aetiology of alzheimer’s disease, PloS one. Available at: https://pubmed.ncbi.nlm.nih.gov/21085570/
Yadong Huang et.al AbstractApolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, Alberts, M. J., Bellosta, S., Brodbeck, J., Chen, H. K., Chou, C.-Y., Cruchaga, C., DeMattos, R. B., Desai, P., Fagan, A. M., Frankel, A. D., Green, M., Grouselle, D., ... Cramer, P. E. (2014, August 27). Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and alzheimer’s diseases. Neurobiology ofDisease.Available at: https://www.sciencedirect.com/science/article/abs/pii/S0969996114002563?via=ihub
Gomez-Pastor et al. Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease Natinal library of medicine DOI: 10.1038/ncomms14405 Available at: https://pubmed.ncbi.nlm.nih.gov/28194040/
Ross, C. A., Aylward, E. H., Wild, E. J., Langbehn, D. R., Long, J. D., Warner, J. H., Scahill, R. I., Leavitt, B. R., Stout, J. C., Paulsen, J. S., Reilmann, R., Unschuld, P. G.,Wexler, A., Margolis, R. L., & Tabrizi, S. J. (2014, March 11). Huntington disease: Natural history, biomarkers and prospects for Therapeutics. Nature News. Available at: https://www.nature.com/articles/nrneurol.2014.24
JONES, L., HUGHES, M., & UNTERSTALLER, U. (2001a). Post-traumatic stress disorder (PTSD) in victims of domestic violence. Trauma, Violence, & Abuse, 2(2), 99– 119. Available at: https://doi.org/ 10.1177/ 1524838001002002001
McKnight Investigators, T. M., Search for more papers by this author, & Fairburn, C. G. (2003, February 1). Risk factors for the onset of eating disorders in adolescent girls: Results of the McKnight Longitudinal Risk Factor Study. American Journal ofPsychiatry. Available at: https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.160.2.248
Garcia, R. (1970, January 1). Neurobiology of fear and specific phobias. Learning & Memory. Available at: https://learnmem.cshlp.org/content/24/9/462.full
Rosen, J. B., Asok, A., & Chakraborty, T. (2015, August 4). The smell of fear: Innate threat of 2,5- dihydro-2,4,5-trimethylthiazoline, a single molecule component of a predator odor. Frontiers. Available at: https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2015.00292/full
Rohan, K. J., Roecklein, K. A., & Haaga, D. A. F. (1970, January 1). Biological and psychological mechanisms of seasonal affective disorder: A review and Integration. Latest TOCRSS. Available at: https://www.ingentaconnect.com/content/ben/cpsr/2009/00000005/00000001/art00003
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006). The circadian basis of winter depression. Proceedings of the National Academy of Sciences, 103(19), 7414–7419. Available at https://doi.org/ 10.1073/pnas.0602425103
David Schlager et.al, Abstract This study of primary care patients sought to estimate the prevalence of and functional impairment associated with winter-seasonal depression. Three hundred three patients visiting a primary care clinic in January or February were assessed for sea, Rosen, L. N., Thompson, C., Hardin, T. A., Rosenthal, N. E., Schlager, D., Magnusson, A., Allen, J. M., Dilsaver, S. C., Blacker, C. V. R., Wells, K. B., Zimmerman, M., Froom, J., & Nelson, E. C. (2004, June 28). Winter Depression and functional impairment among Ambulatory Primary Care Patients. Comprehensive Psychiatry. Available at: https://www.sciencedirect.com/science/article/abs/pii/0010440X9590094C
Bodkin et. al. AbstractSequential subjects (N = 103) presenting for pharmacologic treatment of major depression were examined prior to treatment for history of traumatic experiences. Subjects were also examined for symptoms of posttraumatic stress disorder
(PTSD). Two b, Gold, S. D., Association, A. P., Boscarino, J. A., Brunello, N., Burstein, A., Dreman, S., First, M. B., & Helzer, J. E. (2006, October 19). Is PTSD caused by traumatic stress. Journal ofAnxiety Disorders. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0887618506001368
Michopoulos, V., Rothbaum, A. O., Jovanovic, T., Almli, L. M., Bradley, B., Rothbaum, B. O., Gillespie, C. F., & Ressler, K. J. (2015). Association ofcrpgenetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma. American Journal ofPsychiatry, 172(4), 353–362. Available at: https://doi.org/10.1176/appi.ajp.2014.14020263
Smoller, J. W. (2015, August 31). The genetics of stress-related disorders: PTSD, depression, and anxiety disorders. Available at: Nature News. https://www.nature.com/articles/npp2015266
Nicola M. Grissom, AbstractThe size of an infant at birth, Berridge, K. C., Calegare, B. F. A., Day, J. J., Grayson, B. E., Herva, A., Juhasz, J. R., Mayeur, S., Maym , J. L., Naef, L., Narayanan, N. S., Niculescu, M. D., Non, A. L., Ornoy, A., Papaleo, F., Plagemann, A., Ranade, S. C., Ravelli, A. C., ... Gal ra, C. (2012, November 27). Gestational overgrowth and undergrowth affect neurodevelopment: Similarities and differences from behavior to epigenetics. International Journal ofDevelopmental Neuroscience. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0736574812005977
Nestler, E. J., Pe a, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016). Epigenetic basis of mental illness. The Neuroscientist, 22(5), 447–463. Available at: https://doi.org/10.1177/1073858415608147
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