The Effect of H50Q Mutation on the Interaction between α-Synuclein and Lipid

Ming Zhong

doi:10.54097/hset.v30i.4963

Authors

Ming Zhong

DOI:

https://doi.org/10.54097/hset.v30i.4963

Keywords:

α-synuclein; Lipid; Parkinson's Disease; FPD Mutation; Fluorescence.

Abstract

The abnormal aggregation of α-synuclein (αSyn) is considered as connection with the development of synucleinopathies such as Parkinson’s disease, and lipid could be one of crucial inducers. Familial Parkinson’s disease (FPD) mutation of αSyn can change its properties and may impact its interactions with lipid. In this study, using multiple fluorescence techniques, we found that H50Q mutation can increase αSyn binding to synaptic-like vesicle, which could be helpful to uncover the H50Q mutation-related pathology of αSyn.

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