CRISPR-Cas9 for treatment of bipolar disorder caused by gene mutation

Abstract

Bipolar disorder is a highly debilitating psychiatric illness that is associated with great morbidity and extreme mood changes inducing emotional highs（mania) and lows (depression). Scientists have found that bipolar is a kind of complicated mental illness and difficult to fully heal. Bipolar is caused by three main factors, environmental, biological, and genetic factors. Adverse life events and environmental stress events can induce the onset of affective disorder. This bipolar disorder is one of our most heritable psychiatric disorders. It's second only to autism. The patient has abnormal central neurotransmitter metabolism and corresponding receptor function changes, neuroendocrine dysfunction, mainly the hypothalamic-pituitary-adrenal cortex axis, and hypothalamic-pituitary-thyroid axis dysfunction. Based on researches, the gene mutation is one of the pathogenic factors for bipolar disorder, and there is no therapy has been confirmed that can cure bipolar disorder so far. Thanks to the development of biotechnology, microbiologists developed a new technology. Nowadays, we try to cure bipolar disorder by CRISPR. CRISPR is a new microbiology technology by correcting mutation gene and re-editing it to reduce bipolar disorder incidence. Thus, our study provides a basis for studying gene mutation, therapy of bipolar disorder, and CRISPR technology in the future.