The Mechanism of Antihepatocellular Carcinoma and Toxicity Analysis of Huachanin

Zhetian Xue

doi:10.54097/hset.v6i.971

Authors

Zhetian Xue

DOI:

https://doi.org/10.54097/hset.v6i.971

Keywords:

Mechanism of Antihepatocellular Carcinoma, Toxicity Analysis, Huachanin, Toad.

Abstract

Huachanin is a chemical borrowed from Traditional Chinese Medication practices that is commonly utilized in the treatment of cancer. Its mixture attribute serves in alignment with the typical multiple-target effects of Traditional Chinese Medicine. A majority of researches on Huachanin, however, examine its influences only on single pathways. This review integrates several major mechanisms by which Huachanin acquires hepatoma cancer suppressing functions, namely, the down regulation of Aurora Kinase, induction of apoptosis, and the inhibition of cell autophagy. The review then analyses Huachanin’s cause on nontumor tissue malfunction while suppressing tumor growth, aiming to provide insight into balancing the toxicity and efficacy in Huachanin treatments to maximize its medical potential.

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References

Wu Xiyan, Hui Min, Wang Zhimin. Research progress on the chemical composition of toadstools[J]. Chinese Journal of Experimental Formulation, 2010, 16(14): 207-220.

Ma Snapchi, Zhang Baojing, Deng Xie, et al. Study on the steroidal components of toadstools in Chinese medicine [J]. Advances in Modern Biomedicine, 2009, 9(18): 3519-3522.

Gao Ruilin, Shao Yixiang. Clinical application of toadstool [J]. Chinese clinical rehabilitation, 2006, 30(35): 142-144.

Aurora kinases: Novel therapy targets in cancers. Oncotarget. 2017 Apr 4; 8(14):23937-23954. PMID: 28147341; PMCID: PMC 5410356.

He SH. Study on the mechanism of oncogene AURKA in tumor development[D]. Beijing Peking Union Medical College, 2011.

Wang Jiabao, Xu Zhongwei, Wand Zhimei, Dai Erqing, Xu Ruicheng. Study on the mechanism of down-regulation of aurora kinase expression and promotion of cell cycle block in hepatocellular carcinoma by the active ingredients of Toadstool [J]. Chinese herbal medicine, 2017, 48(18):3796-3801.

Guo, S.C., Zeng, D. (2000). Caspase family and apoptosis. Chinese Journal of Cell Biology, 06 (4), 163-169.

Wang, D.L. Screening, identification and mechanism of action of the effective components of Huachanin against hepatocellular carcinoma [D]. Shandong University, 2010.

Lozy F, Karantza V. Autophagy and cancer cell metabolism [J]. Semin Cell Dev Biol. 2012, 23(4):395-401.

Eskelinen EL. The dual role of autophagy in cancer [J]. Curr Opin Pharmacol. 2011, 11(4):294-300.

Chen N, Karantza-Wadsworth V. Role and regulation of autophagy in cancer [J]. Biochim Biophys Acta. 2009, 1793(9):1516-1523.

Song YJ, Zhang SS, Guo XL. Autophagy contributes to the survival of CD133+ HCC stem cells in the hypoxia and nutrient-deprived tumor microenvironment [J]. Cancer Lett.

Suzuki SW, Onodera J, Ohsumi Y. Starvation-induced cell death in autophagy-deficient yeast mutants results from mitochondrial dysfunction [J]. 2011, 6(2): e17412.

Yang S, Wang X, Contino G. Pancreatic cancers require autophagy for tumor growth [J]. Genes Dev. 2011, 25(7):717-729.

Gewirtz DA. Autophagy, senescence and tumor dormancy in cancer therapy [J] Autophagy. 2009, 5(8):1232-1234.

Shanwei, S., & Yi, L. West China Journal of Stomatology, 2015, 33(1), 98-103.

Han Mengfei. The role and mechanism of autophagy in bufalin-induced apoptosis and aerobic glycolysis in human hepatoma cells [D]. Chinese People's Liberation Army Naval Medical College, 2020. DOI:10.26998/d.cnki.gjuyu.2020.000039.

Liang Xiaoping, Zhang Zheng, Hu Ping. A metabolomic study on the acute toxicity of toad venom [J]. Journal of Chemistry in Colleges and Universities, 2011, 32(1): 38-43.

Kennedy DJ, Vetteth S, Periyasamy SM, et al. Pathogenesis of experimental uremic cardiomyopathy [J]. High Blood Pressure, 2006, 47(3): 488-495.

Bick RJ, Poindexter BJ, Sweney RR, et al. The effect of traditional Chinese medicine "Chen Su" on the instantaneous heat of isolated cardiomyocytes. Cardiotoxicity due to more than just blockade of Na, K-ATPase [J]. Life Science, 2002,72(6):699-709.

Armstrong SC, Shivell LC, Ganote CE. Simian hemorrhage and osmotic fragility are associated factors of irreversible damage in isolated rabbit cardiomyocytes after preconditioning [J]. J Mol Cell Cardiol, 2001, 33(1): 149-160.

Xie JT, Wang H, Attele AS, et al. Effects of resibu fogenin from toad venom on Purkinje fibers in vitro [J]. Chinese Medicine, 2000, 28(2): 187-196.

Chinese Materia Medica Editorial Committee of the State Administration of Traditional Chinese Medicine. Chinese Materia Medica [M]. Shanghai. Shanghai Science and Technology Press, 1999. Shanghai: Shanghai Science and Technology Press, 1999. 8362-8363.

Ma H, Zhou J, Jiang J, et al. The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice [J]. Exp Toxicol Pathol, 2012, 64(5): 417-423.

Zhong SHH, Hu TJ, Hao LH, Zhao H, Deng YH, He JK. Acute and subchronic toxicity study of toadstool injection [J]. Chinese Journal of Veterinary Medicine,2013,49(03):68-71.

Jiang Jiejun, Zhou Jing, Ma Hongyue, You Fenqiang, Duan Jingran, Ding Anwei. Study on the toxic effects and material basis of Toadstool on guinea pig isolated heart [J]. Chinese Experimental Formulary Miscellaneous. DOI:10.13422/j.cnki.syfjx.2011.17.078.