Current progress of immunotherapy based on NK cell in cancer therapy
DOI:
https://doi.org/10.54097/hset.v54i.9776Keywords:
Cancer, NK cell-based immunotherapy, NK cellsAbstract
Cancer generally refers to malignant tumor, including carcinoma, sarcoma and carcinosarcoma. This disease is caused by malignant cell hyperplasia. It is invasive and metastable. It is manifested by the continuous growth of a local mass of the body that destroys the normal tissue structure and can be transferred to other sites. It has been reported that there will be about 20 million new cases of cancer in 2020 and half of all cancer patients will die. Surgery, chemotherapy and radiotherapy, as the three standard treatment methods for cancer, plays an vital role in improving the survival rate and prolonging the survival time of cancer patients. In recent years, researchers have focused on the immune mechanism of tumors to explore the treatment of malignant tumors. Driven by the rapid development of modern molecular biology and gene engineering technology, immunotherapy has been paid more and more attention, showing good effect and application prospects, has become the world's recognized malignancy of the fourth treatment mode. Among these, natural killer cells (NK) fight cancer through their cytolytic function and the production of IFN-γ. One of the primary clinical objectives is to use their abilities for tumour immunotherapy. This article looks at advances in NK cell-based tumor therapy.
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