Trends for CRISPR and CAR-T in the future medical field

Abstract

CRISPR as a protein editor that identifies specific genes and then sending off transcriptions to later be used for the new strand of DNA that is altered so that the problems within the previous codes would be fixed. In addition, the other method, CAR-T, this is a newer method that edits cells directly and treats diseases such as cancer and tumors. Using human autologous, allogeneic, or heterogeneic (non-human) cells that have been altered in vitro and then injected (or implanted) back into the body is referred to as cell therapy. CAR-T cell therapy, one of them, is an adoptive cell immunotherapy that has emerged recently. It works primarily by combining the specificity of chimeric antigen receptor with the immune effect of T cells, and then killing malignant tumor cells through specific recognition. The technology is also being enhanced and expanded to other disease areas given its promise and benefits. There are many generations of this, and each has been improved. For now, the current technology still has posed limitations on CAR-T, but it is progressing at a steady pace. Therefore, there are positive futures for the technology of gene engineering. From the successful cases that has been proceeded, this also proved the development of this technology in the future. This review systematically summarizes CRISPR and CART, these are two ways that we use as cell and gene engineering.