Analysis of Pharmaceutical Processes and Related Problems Using Biotechnology: Taking EPO Production as an Example

Authors

  • Xuyuan Zhang

DOI:

https://doi.org/10.54097/7hv9w638

Keywords:

EPO; biotechnology; process; protein drugs.

Abstract

Biotechnology is increasingly being used in pharmaceutical production. Solve the problems encountered in the current pharmaceutical process to help more efficient production. It is now possible to produce protein drugs such as EPO with relative maturity. People can use related biotechnology to solve some of the problems encountered in production. However, many biotechnology applications have not yet been integrated into the pharmaceutical process. This study first introduced the role of EPO in human body, the mechanism of EPO and the application field of EPO. Then, the production process and biotechnology involved in EPO generic drugs are analyzed. Finally, the existing shortcomings of relevant processes, processes, technologies and optimization methods are analyzed, and a production model suitable for most protein drugs is obtained. This study provides reference suggestions for the production process and technical optimization of protein drugs for future research, but does not analyze drugs other than protein drugs. Future research can focus on the pharmaceutical process of nucleic acid drugs, polysaccharide drugs and other types of drugs and related problems analysis, and can also supplement and optimize the results of this research.

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References

Jiang Hengbo, Zhang Xihe, CAI Runfa et al. Application and optimization of pharmaceutical technology in the production of biological agents . Contemporary Chemical Research,2023,(16):

Chen Yilun, Hui Yu, Wu Kefeng, et al. Clinical effect of erythropoietin in patients with anemia after renal transplantation . Journal of Modern Urology, 2019,28(05):424-428.

Zhang Kexin, Zhu Minxia. The role of erythropoietin in the protective mechanism of cerebral ischemia and related Chinese medicine intervention . China's modern applied pharmacy, 2020, 5 (11) : 1397-1401.

Xie Guiling, Wang Dongwei, Zhang Lili, et al. Effect of dexmedetomidine on JAK1/STAT1 signaling pathway during cerebral ischemia and reperfusion in rats . Medical theory and practice, 2019, 32 (8) : 1109-1110 + 1116.

Qin Huaping, Yang Changchun, Wang Qiang, et al. Effect of hypothermia on hippocampal Bax expression and its relationship with apoptosis in rats with global cerebral ischemia. Of the medical journal, 2017 (12) : 1286-1289.

Zheng Tianliang, Chen Xiaocui. Clinical effect of recombinant human erythropoietin combined with component blood transfusion on chronic anemia . Clinical medical research and practice, 2022, 7 (33) : 30-34.

Wang Qianqian, Liu Yaqi, Qu Yan et al. Recombinant e. coli whole-cell catalysis preparation pseudouridine. Journal of biological engineering,2023, 1-14

Ren Ziqiang, Wang Mengcan, Zhang Hailing et al. The research progress of CHO cells express glycoprotein . Chinese journal of biotechnology, and 2022, (6) : 54-65.

Huo Yunfei, Kou Buxin, Chai Mengyin et al. Construction and functional identification of TP53BP2 shRNA lentiviral vector in vitro . Journal of Practical Hepatology, 2019,26(02):164-168.

Yan Cuixia, Yin Hongrui, Shi Fangliang et al. Determination of molecular component ratio of urokinase for injection by Ion-exchange chromatography combined with molecular exclusion chromatography . Journal of Pharmaceutical Analysis, 2019,43(01):4-11.

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Published

15-04-2024