mRNA Vaccine: The Starting Point of the Human Body Revolution

Wenhao Jiang

doi:10.54097/4edpd319

Authors

Wenhao Jiang

DOI:

https://doi.org/10.54097/4edpd319

Keywords:

mRNA vaccine, base modification, +1 frameshift.

Abstract

In the face of the initially high incidence of allergic reactions to the mRNA vaccines against COVID-19, scientists' explanations fell short. To address this, a study delved into the history of in vitro-transcribed mRNA. The researcher proposes that a more plausible reason lies in +1 ribosomal frameshifting of certain tRNAs during the translation of in vitro transcribed mRNA in vivo. While not the first instance of experiments, the underlying mechanism remains unclear. Based on this, I have conceived an explanatory principle: "tRNA stalling leading to +1 frameshifting due to collisions." Although further experiments are needed to validate, the theoretical explanation holds a certain degree of possibility. This concept may contribute to addressing the issue of "+1 frameshifting," enhancing the functionality of in vitro-transcribed mRNA.

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