The Role of Ketogenic Diet in Gut Microbiota

Abstract

Several studies point to a vital role for gut microbiota (GM) in preventing disease and reducing inflammation in humans. Gut microbiota has an important relationship with the human brain-gut axis, and the biological metabolites they produce are closely linked to the function of nervous system. Ketogenic diet (KD) is thought to be effective on the makeup of GM and thus affecting human health due to its low calorie and fiber consumption. Recent research has found KD can affect GM composition under pathological conditions, such as drug refractory epilepsy (DRE). So as to achieve the purpose of treating DRE. Therefore, this article aims to explore the effect of KD on the human GM and explore whether it has important implications for human health. Finally, we found that KD can modulate human health by affecting gut microbiota richness, increasing some microbes that can produce beneficial metabolites, and reducing some pro-inflammatory microbes to prevent and treat specific diseases.